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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda
Journal of Natural Products, Volume 69, No. 1, Year 2006
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Description
An ethnopharmacological investigation was conducted among the Baka pygmies of Dja biosphere reserve (Cameroon) to collect information on the antimalarial plants used in their daily life. Holarrhena floribunda is one of those plants. Extracts of the stem barks of H. floribunda showed remarkable inhibitory activity against drug-resistant strains of Plasmodium falciparum at doses of 1.02-18.53 μg/mL when tested in vitro against two parasite clones designated as Indochina (W-2) and Sierra Leone (D-6). The aqueous extract was the most active against Indochina (W-2), with IC50 values of 1.02 μg/mL, while the ethanolic extract appeared to be the most active against Sierra Leone (D-6), with an IC50 of 4.33 μg/mL. The bioassay-guided fractionation of the neutral fraction of the crude extract led to the isolation of lupeol (1) and its three new long-chain fatty acid ester derivatives, namely, 3-O-(3′-hydroxyeicosanoyl)lupeol (2), 3-O-[(2′-(tetracosyloxy) acetyl]lupeol (3), and 3-O-[(1″-hydroxyoctadecyloxy)-2′- hydroxypropanoyl]lupeol (4). These new compounds displayed some in vitro inhibition activity against the chloroquine-resistant strain FCR-3 isolated from Gambia and the chloroquine-sensitive standard strain 3D7. The hydroxy group of the fatty acid side chain appears to decrease the observed activity. © 2006 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Fotie, Jean
Canada, Montreal
Université Mcgill
Bohle, D. Scott
Canada, Montreal
Université Mcgill
Leimanis, Mara L.
Canada, Sainte-anne-de-bellevue
Mcgill University, Macdonald Campus
Georges, Elias
Canada, Sainte-anne-de-bellevue
Mcgill University, Macdonald Campus
Rukunga, Geoffrey Muriki
Kenya, Nairobi
Kenya Medical Research Institute
Nkengfack, Augustin Ephrem
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 154
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1021/np050315y
ISSN:
01633864
Study Locations
Cameroon
Gambia
Sierra Leone