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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A comprehensive model of predictors of quality of life in older adults with schizophrenia: results from the CSA study
Social Psychiatry and Psychiatric Epidemiology, Volume 56, No. 8, Year 2021
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Description
Background: Numerous factors are known to influence quality of life of adults with schizophrenia. However, little is known regarding the potential predictors of quality of life in the increasing population of older adults with schizophrenia. The main objective of the present study was to propose a comprehensive model of quality of life in this specific population. Methods: Data were derived from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) study, a large (N = 353) multicenter sample of older adults with schizophrenia or schizoaffective disorder recruited from French community mental-health teams. We used structural equation modeling to simultaneously examine the effects of six broad groups of clinical factors previously identified as potential predictors of quality of life in this population, including (1) severity of general psychopathology, (2) severity of depression, (3) severity of cognitive impairment, (4) psychotropic medications, (5) general medical conditions and (6) sociodemographic characteristics. Results: General psychopathology symptoms, and in particular negative and depressive symptoms, cognitive impairment, reduced overall functioning and low education were significantly and independently associated with diminished quality of life (all p < 0.05). Greater number of medical conditions and greater number of antipsychotics were also independently and negatively associated with quality of life, although these associations did not reach statistical significance in sensitivity analyses, possibly due to limited statistical power. Conclusion: Several domains are implicated in quality of life among older adults with schizophrenia. Interventions targeting these factors may help improve importantly quality of life of this vulnerable population. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Authors & Co-Authors
Hoertel, Nicolas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Institut de Psychiatrie et Neurosciences de Paris Ipnp
France, Paris
Université Paris Cité
Blanco, Carlos V.
United States, Bethesda
National Institute on Drug Abuse Nida
Dubertret, Caroline
France, Paris
Institut de Psychiatrie et Neurosciences de Paris Ipnp
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Adès, Jean
Unknown Affiliation
Amado, Isabelle Reine
Unknown Affiliation
Guillin, Olivier
Unknown Affiliation
Haffen, Emmanuel
Unknown Affiliation
Jalenques, Isabelle
Unknown Affiliation
Kébir, Oussama
Unknown Affiliation
Krebs, Marie Odile
Unknown Affiliation
Leboyer, Marion
Unknown Affiliation
Llorca, Pierre Michel
Unknown Affiliation
Mahi, Mohammed
Unknown Affiliation
Nubukpo, Philippe
Unknown Affiliation
Pringuey, Dominique J.
Unknown Affiliation
Sánchez-Rico, Marina
Unknown Affiliation
Sechter, Daniel
Unknown Affiliation
Verdoux, Hélène
Unknown Affiliation
Statistics
Citations: 10
Authors: 18
Affiliations: 10
Identifiers
Doi:
10.1007/s00127-020-01880-2
ISSN:
09337954
Research Areas
Disability
Mental Health
Study Design
Cross Sectional Study
Cohort Study