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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Engaging diverse communities participating in clinical trials: Case examples from across Africa
Malaria Journal, Volume 9, No. 1, Article 86, Year 2010
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Description
Background: In the advent of increasing international collaborative research involving participants drawn from populations with diverse cultural backgrounds, community engagement becomes very critical for the smooth conduction of the research. The African Malaria Network Trust (AMANET) is a pan-African non-governmental organization that sponsors and technically supports malaria vaccine trials in various African countries. Case description. AMANET sponsored phase Ib or IIb clinical trials of several malaria vaccine candidates in various Africa countries. In Burkina Faso, Mali and Tanzania trials of the merozoite surface protein 3 - in its Long Synthetic Peptide configuration (MSP3 LSP) - were conducted. In Mali, the apical membrane antigen 1 (AMA1) was tested, while a hybrid of glutamate rich protein (GLURP) and MSP3 (GMZ2) was tested in Gabon. AMANET recognizes the importance of engaging with the communities from which trial participants are drawn, hence community engagement was given priority in all project activities conducted in the various countries. Discussion and evaluation. Existing local social systems were used to engage the communities from which clinical trial participants were drawn. This article focuses on community engagement activities employed at various AMANET-supported clinical trial sites in different countries, highlighting subtle differences in the approaches used. The paper also gives some general pros and cons of community engagement. Conclusions. Community engagement enables two-way sharing of accurate information and ideas between researchers and researched communities, which helps to create an environment conducive to smooth research activities with enhanced sense of research ownership by the communities. © 2010 Nyika et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Nyika, Aceme
Tanzania, Dar es Salaam
African Malaria Network Trust Amanet
Chilengi, Roma
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Ishengoma, Deus Simon
Tanzania, Tanga
National Institute for Medical Research Tanga
Mtenga, Sally Mmanyi
Tanzania, Ifakara
Ifakara Health Institute
Thera, Mahamadou Ali
Mali, Bamako
University of Bamako
Sissoko, Mahamadou Soumana
Mali, Bamako
University of Bamako
Lusingu, John Peter Andrea
Tanzania, Tanga
National Institute for Medical Research Tanga
Tiono, Alfred Bewendtaoré
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Sirima, Sodiomon Bienvenu
Burkina Faso, Ouagadougou
Centre National de Recherche et de Formation Sur le Paludisme
Lemnge, Martha M.M.
Tanzania, Tanga
National Institute for Medical Research Tanga
Kilama, Wen L.
Tanzania, Dar es Salaam
African Malaria Network Trust Amanet
Statistics
Citations: 52
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1186/1475-2875-9-86
e-ISSN:
14752875
Research Areas
Infectious Diseases
Study Locations
Burkina Faso
Gabon
Mali
Tanzania