Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Analyses of pediatric isolates of Cryptococcus neoformans from South Africa
Journal of Clinical Microbiology, Volume 49, No. 1, Year 2011
Notification
URL copied to clipboard!
Description
Compared to the incidence in adults, cryptococcosis is inexplicably rare among children, even in sub-Saharan Africa, which has the highest prevalence of coinfection with HIV and Cryptococcus neoformans. To explore any mycological basis for this age-related difference in the incidence of cryptococcosis, we investigated isolates of C. neoformans recovered from pediatric and adult patients during a 2-year period in South Africa. From reports to the Group for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA), we reviewed all cases of cryptococcosis in 2005 and 2006. We analyzed one isolate of C. neoformans from each of 82 pediatric patients (<15 years of age) and determined the multilocus sequence type (ST), mating type, ploidy, and allelic profile. This sample included isolates of all three molecular types of serotype A or C. neoformans var. grubii (molecular types VNI, VNII, and VNB) and one AD hybrid. Seventy-seven (94%) of the strains possessed the MATα mating type allele, and five were MATa. Seventy-five (91%) were haploid, and seven were diploid. A total of 24 different STs were identified. The ratios of each mating type and the proportion of haploids were comparable to those for the isolates that were obtained from 86 adult patients during the same period. Notably, the most prevalent pediatric ST was significantly associated with male patients. Overall, these pediatric isolates exhibited high genotypic diversity. They included a relatively large percentage of diploids and the rarely reported MATa mating type. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3020432/bin/supp_49_1_307__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3020432/bin/supp_49_1_307__1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3020432/bin/supp_49_1_307__2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3020432/bin/supp_49_1_307__3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3020432/bin/supp_49_1_307__4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3020432/bin/supp_49_1_307__5.pdf
Authors & Co-Authors
Miglia, Kathleen J.
United States, Durham
Duke University Medical Center
Govender, Nelesh P.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
South Africa, Johannesburg
Nicd
Rossouw, Jennifer
South Africa, Johannesburg
National Institute for Communicable Diseases
Meiring, Susan T.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
Nicd
Mitchell, Thomas G.
United States, Durham
Duke University Medical Center
Vasaikar, Sandeep D.
Unknown Affiliation
Smith, Peter G.
Unknown Affiliation
Van Rensburg, Nolan Janse
Unknown Affiliation
Mo¨ller, Andre´
Unknown Affiliation
Pretorius, Anne Marié
Unknown Affiliation
Sein, Pyu Pyu
Unknown Affiliation
Hoosen, Anwar Ahmed
Unknown Affiliation
Lekalakala, R. M.
Unknown Affiliation
Ngwira, Donald
Unknown Affiliation
Perovic, Olga
Unknown Affiliation
Feldman, Charles
Unknown Affiliation
Karstaedt, Alan S.
Unknown Affiliation
Dove, Michael G.
Unknown Affiliation
Lindeque, Kathy
Unknown Affiliation
Meyer, Linda
Unknown Affiliation
Wadula, Jeannette
Unknown Affiliation
Ahmed, Khatija
Unknown Affiliation
Weldhagen, Gerhard F.
Unknown Affiliation
Vanmali, Trusha
Unknown Affiliation
Sturm, Willem A.
Unknown Affiliation
Bhola, Prathna
Unknown Affiliation
Moodley, Prashini
Unknown Affiliation
Seetharam, Sharona
Unknown Affiliation
Sithole, Sindiswe
Unknown Affiliation
Dawood, Haiima
Unknown Affiliation
Harvey, Stan
Unknown Affiliation
Jooste, Pieter L.
Unknown Affiliation
Cilliers, D.
Unknown Affiliation
Hamese, Ken
Unknown Affiliation
Bauer, Keith
Unknown Affiliation
Hoyland, Greta
Unknown Affiliation
Mutanda, Charles
Unknown Affiliation
Lebudi, Jacob
Unknown Affiliation
Whitelaw, Andrew C.
Unknown Affiliation
Hoffman, Rena
Unknown Affiliation
Liebowitz, Lynne D.
Unknown Affiliation
Wasserman, Elizabeth
Unknown Affiliation
Brink, Adrian John
South Africa, Pretoria
Ampath Laboratories
Heney, Claire
South Africa, Johannesburg
Lancet Laboratories
Senekal, Marthinus
South Africa, Claremont
Pathcare
Schuchat, Anne
South Africa, Johannesburg
Cdc
Schrag, Stephanie J.
South Africa, Johannesburg
Cdc
Klugman, K. P.
South Africa, Johannesburg
Nicd
von Gottberg, Anne M.
South Africa, Johannesburg
Nicd
de Gouveia, Linda D.
South Africa, Johannesburg
Nicd
Keddy, Karen Helena
South Africa, Johannesburg
Nicd
Frean, John Andrew
South Africa, Johannesburg
Nicd
Quan, Vanessa Cecilia
South Africa, Johannesburg
Nicd
Cohen, Cheryl D.
South Africa, Johannesburg
Nicd
Prentice, Elizabeth
South Africa, Johannesburg
Nicd
McCarthy, Kerrigan M.
South Africa, Johannesburg
Nicd
Sooka, Arvinda
South Africa, Johannesburg
Nicd
Davidsson, L. A.
South Africa, Johannesburg
Nicd
Gould, Susan M.
South Africa, Johannesburg
Nicd
Patel, Jay
South Africa, Johannesburg
Nicd
Cheyip, Mireille Y.N.C.K.
South Africa, Johannesburg
Nicd
Statistics
Citations: 61
Authors: 61
Affiliations: 8
Identifiers
Doi:
10.1128/JCM.01277-10
ISSN:
00951137
e-ISSN:
1098660X
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
South Africa
Participants Gender
Male