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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association between birth outcomes and aflatoxin B
1
biomarker blood levels in pregnant women in Kumasi, Ghana
Tropical Medicine and International Health, Volume 15, No. 2, Year 2010
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Description
Objective To investigate the association between birth outcomes and blood levels of aflatoxin B1 (AFB1)-lysine adduct in pregnant women in Kumasi, Ghana. Method A cross-sectional study of 785 pregnant women attending antenatal clinic was conducted. Aflatoxin B1 (AFB1)-lysine adduct levels were determined by high performance liquid chromatography (HPLC) on blood taken after delivery. The birth outcomes considered were small for gestation age, low birthweight, preterm delivery and stillbirth. Participants were divided into quartiles based on the distribution of aflatoxin B 1-lysine adducts in pg/mg albumin ('low': ≤2.67, 'moderate': >2.67 to ≤4.97, 'high': >4.97 to ≤11.34, 'very high': >11.34). Statistical analysis involved models that included socio-demographic variables and other potential confounders. Results The average AFB1-lysine adduct level in maternal serum was 10.9 ± 19.00 pg/mg albumin (range = 0.44-268.73 pg/mg). After adjusting for socio-demographic variables and potential confounding factors, participants in the highest AFB 1-lysine quartile with 'very high' AFB1-lysine level (>11.34 pg/mg) were more likely to have low birthweight babies (OR, 2.09; 95% CI, 1.19-3.68), and showed a trend of increasing risk for low birthweight (Ptrend = 0.007) compared to participants in the lowest quartile. Conclusion This study adds to the growing body of evidence that aflatoxins may increase the risk of adverse birth outcomes. The findings have implications for targeted nutritional education of pregnant women in areas with high levels of aflatoxin contamination of foods. © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Shuaib, Faisal Mohammed B.
Unknown Affiliation
Jolly, Pauline E.
Unknown Affiliation
Ehiri, John E.
Unknown Affiliation
Yatich, Nelly J.
Unknown Affiliation
Jiang, Yi
Unknown Affiliation
Funkhouser, Ellen M.
Unknown Affiliation
Person, Sharina D.
Unknown Affiliation
Wilson, Craig M.
Unknown Affiliation
Ellis, William Otoo
Unknown Affiliation
Wang, Jiasheng
Unknown Affiliation
Williams, Jonathan H.
Unknown Affiliation
Statistics
Citations: 135
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1111/j.1365-3156.2009.02435.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Ghana
Participants Gender
Female