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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ocular hypotension and hypotony in multibacillary leprosy patients; At diagnosis, during and after completion of multidrug therapy
Indian Journal of Leprosy, Volume 82, No. 4, Year 2010
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Description
The prevalence and incidence of ocular hypotony (IOP<7 mm Hg) and hypotension (IOP<10 mm Hg) and factors associated with them were determined in a Leprosy Referral Centre at Tamilnadu, India. Applanation intraocular pressures were measured every six months in a cohort of newly diagnosed multibacillary (MB) leprosy patients who were followed-up during the two year period of multidrug therapy (MDT) and for five years thereafter. Transient hypotony was present in two patients at the time of diagnosis, in 3 patients during MDT and in 9 patients after MDT with a cumulative prevalence of 4.65%. Transient ocular hypotension was present in 24 patients (8%) at disease diagnosis. 25 patients developed hypotension during MDT that was associated with trichiasis (HR 8.83 95% CI 2.06,37.78 p=0.003) and flare or/and cells (HR 4.60 95% Cl 1.08, 19.64 p=0.039). 29 patients developed ocular hypotension after MDT that was associated with punctate keratitis and uveal involvement. In general, MB leprosy patients with hypotension had a mean IOP of 12.60 mm Hg which differed significantly (p<0.0001) from the mean IOP of 14.9 mm Hg in those who did not have hypotension. Transient hypotension and hypotony in MB leprosy patients are associated with signs of intraocular inflammation. © Hind Kusht Nivaran Sangh, New Delhi.
Authors & Co-Authors
Daniel, Ebenezer
United States, Philadelphia
University of Pennsylvania
Rao, P. S.S.Sundar
India, New Delhi
The Leprosy Mission Trust India
Ffytche, Timothy J.
United Kingdom, London
Hospital for Tropical Diseases
Courtright, Paul D.
Tanzania, Iringa
Tumaini University
Statistics
Citations: 4
Authors: 4
Affiliations: 4
Identifiers
ISSN:
02549395
Study Design
Cross Sectional Study
Cohort Study