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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Dichapetalins from dichapetalum species and their cytotoxic properties
Phytochemistry, Volume 94, Year 2013
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Description
Six dichapetalins named dichapetalins N-S were isolated from Dichapetalum mombuttense, Dichapetalum zenkeri and Dichapetalum leucosia. They were accompanied in the same plants by the known dichapetalins A, B, C, I, L and M. The structures of the compounds were elucidated by 1D and 2D NMR experiments and mass spectrometry. They all possessed the dammarane skeleton substituted at position C-3 by a C6-C2 unit forming a 2-phenylpyran moiety. All contained a lactone ring in the side chain except dichapetalins O, Qand R, in which this ring was replaced by a lactol. Dichapetalin Qand R were also the first dichapetalins bearing a tertiary methyl and a double bond instead of the cyclopropane of the dammaranes. All these compounds were assayed against cancer cell lines HCT116 and WM 266-4 and displayed cytotoxic and anti-proliferative activities in the 10-6 to 10-8 M range. © 2013 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Long, Christophe
France, Castres
Pierre Fabre Recherche et Devéloppement
Aussagues, Yannick
France, Castres
Pierre Fabre Recherche et Devéloppement
Molinier, Nicolas
France, Castres
Pierre Fabre Recherche et Devéloppement
Marcourt, Laurence
France, Castres
Pierre Fabre Recherche et Devéloppement
Vendier, Laure
France, Toulouse
Lcc Laboratoire de Chimie de Coordination
Samson, Arnaud
France, Castres
Pierre Fabre Recherche et Devéloppement
Poughon, Valérie
France, Castres
Pierre Fabre Recherche et Devéloppement
Mutiso, Patrick B.Chalo
Kenya, Nairobi
University of Nairobi
Ausseil, Frédéric
France, Castres
Pierre Fabre Recherche et Devéloppement
Sautel, François
France, Castres
Pierre Fabre Recherche et Devéloppement
Arimondo, Paola Barbara
France, Castres
Pierre Fabre Recherche et Devéloppement
Massiot, Georges S.
France, Castres
Pierre Fabre Recherche et Devéloppement
Statistics
Citations: 19
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/j.phytochem.2013.03.023
ISSN:
00319422
Research Areas
Cancer