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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Cryptosporidiosis in HIV/AIDS patients in Kenya: Clinical features, epidemiology, molecular characterization and antibody responses
American Journal of Tropical Medicine and Hygiene, Volume 91, No. 2, Year 2014
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Description
We investigated the epidemiological and clinical features of cryptosporidiosis, the molecular characteristics of infecting species and serum antibody responses to three Cryptosporidium-specific antigens in human immunodeficiency virus (HIV) /acquired immunodeficiency syndrome (AIDS) patients in Kenya. Cryptosporidium was the most prevalent enteric pathogen and was identified in 56 of 164 (34%) of HIV/AIDS patients, including 25 of 70 (36%) with diarrhea and 31 of 94 (33%) without diarrhea. Diarrhea in patients exclusively infected with Cryptosporidium was significantly associated with the number of children per household, contact with animals, and water treatment. Cryptosporidium hominis was the most prevalent species and the most prevalent subtype family was Ib. Patients without diarrhea had significantly higher serum IgG levels to Chgp15, Chgp40 and Cp23, and higher fecal IgA levels to Chgp15 and Chgp40 than those with diarrhea suggesting that antibody responses to these antigens may be associated with protection from diarrhea and supporting further investigation of these antigens as vaccine candidates. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Wanyiri, Jane W.
United States, Boston
Tufts University School of Medicine
United States, Baltimore
Johns Hopkins University
Kanyi, Henry Muriuki
United States, Boston
Tufts University School of Medicine
Kenya, Nairobi
Kenya Medical Research Institute
Maina, Samuel
United States, Boston
Tufts University School of Medicine
Kenya, Nairobi
Kenya Medical Research Institute
Wang, David E.
United States, Boston
Tufts University School of Medicine
United States, Boston
Tufts Medical Center
Steen, Aaron
United States, Boston
Tufts University School of Medicine
Ngugi, Paul Waweru
United States, Boston
Tufts University School of Medicine
Kenya, Nairobi
Kenyatta National Hospital
Kamau, Timothy
United States, Boston
Tufts University School of Medicine
Kenya, Nairobi
Kenya Medical Research Institute
Waithera, Tabitha
United States, Boston
Tufts University School of Medicine
Kenya, Nairobi
Kenya Medical Research Institute
O'Connor, Roberta M.
United States, Boston
Tufts University School of Medicine
United States, Boston
Tufts Medical Center
Kimani, Gachuhi G.
United States, Boston
Tufts University School of Medicine
Kenya, Nairobi
Kenya Medical Research Institute
Wamae, Claire Njeri
United States, Boston
Tufts University School of Medicine
Kenya, Nairobi
Kenya Medical Research Institute
Mwamburi, Mkaya
United States, Boston
Tufts University School of Medicine
United States, Medford
Tufts University
Ward, Honorine D.
United States, Boston
Tufts University School of Medicine
United States, Boston
Tufts Medical Center
Statistics
Citations: 54
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.4269/ajtmh.13-0254
ISSN:
00029637
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Kenya