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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Design, synthesis and evaluation of potent thymidylate synthase X inhibitors
Bioorganic and Medicinal Chemistry Letters, Volume 18, No. 12, Year 2008
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Description
Three synthesized series of compounds based on a thiazolidine core allowed identification of potent inhibitors of thymidylate synthase X. The evaluation of the catalytic activity of the enzyme in the presence of these molecules revealed two distinct classes of compounds that inhibit ThyX with submicromolar concentrations, which could lead, after optimization, to effective inhibitors with potential biomedical interest. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Boum, Yap I.
France, Gif-sur-yvette
Université Paris-saclay
Jaber, Nada
France, Paris
École Nationale Supérieure de Chimie de Paris
France, Paris
Université Paris Cité
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Inserm
France, Reims
Institut de Chimie Moléculaire de Reims Icmr
Scherman, Daniel
France, Paris
École Nationale Supérieure de Chimie de Paris
France, Paris
Université Paris Cité
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Inserm
France, Reims
Institut de Chimie Moléculaire de Reims Icmr
Myllykallio, Hannu
France, Gif-sur-yvette
Université Paris-saclay
Herscovici, Jean
France, Paris
École Nationale Supérieure de Chimie de Paris
France, Paris
Université Paris Cité
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Inserm
France, Reims
Institut de Chimie Moléculaire de Reims Icmr
Statistics
Citations: 36
Authors: 5
Affiliations: 6
Identifiers
Doi:
10.1016/j.bmcl.2008.04.080
ISSN:
0960894X