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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic
International Journal of Tuberculosis and Lung Disease, Volume 14, No. 6, Year 2010
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Description
Multidrug-resistant (MDR) strains were identified in 40% of 54 strains from patients presenting with tuberculosis (TB) treatment failure or relapse in Bangui, Central African Republic. Results obtained with the MTBDRplus line-probe assay or rpoB sequencing were 86% concordant with rifampicin (RMP) resistant phenotypes, while the amplification refractory mutation system test was 71% concordant. No mutation was found in RMP-susceptible strains. MTBDRplus and sequencing were concordant with the detection of the S315T mutation in katG in 95% of MDR strains. Sequencing of pncA suggested pyrazinamide resistance in 50% of MDR strains. Knowledge of these resistances should help to implement treatment in low-income countries. © 2010 The Union.
Authors & Co-Authors
Minime-Lingoupou, Fanny
Central African Republic, Bangui
Institut Pasteur de Bangui
France, Paris
Institut Pasteur, Paris
Pierre-Audigier, Catherine
France, Paris
Institut Pasteur, Paris
Kassa-Kelembho, Eric
Central African Republic, Bangui
Institut Pasteur de Bangui
France, Paris
Institut Pasteur, Paris
Barilone, N.
France, Paris
Institut Pasteur, Paris
Zandanga, Germain
Central African Republic, Bangui
Institut Pasteur de Bangui
Rauzier, Jean
France, Paris
Institut Pasteur, Paris
Cadet-Daniel, Véronique
France, Paris
Institut Pasteur, Paris
Le Faou, Alain E.
Central African Republic, Bangui
Institut Pasteur de Bangui
Gicquel, Brigitte M.E.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 9
Authors: 9
Affiliations: 2
Identifiers
ISSN:
10273719
Research Areas
Cancer
Infectious Diseases
Study Locations
Central African Republic