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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Helicobacter pylori in apparently healthy children aged 0-12 years in urban Kampala, Uganda: A community-based cross sectional survey
BMC Gastroenterology, Volume 10, Article 62, Year 2010
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Description
Background: Helicobacter pylori is one of the most common causes of bacterial infection in human beings. Studies have showed a high prevalence of Helicobacter pylori among people in low-income countries and colonization early in life. A monoclonal antigen test, performed on faeces, HpSA®ImmunoCardSTAT, has a high sensitivity, specificity and accuracy and the faecal test can be performed in all ages, also in resource-limited settings. The main objective of this study was to determine the prevalence and factors associated with Helicobacter pylori colonization in apparently healthy children aged 0-12 years in urban Kampala, Uganda.Method: We tested 427 apparently healthy children, age 0-12 years (211 males, 216 females), in a cross sectional survey for Helicobacter pylori colonization using HpSA ®ImmunoCardSTAT. A short standardized interview with socio-demographic information and medical history was used to assess risk factors.Results: The overall prevalence of Helicobacter pylori in the 427 children was 44.3% (189 out of 427). Early colonization was common, 28.7%, in children younger than 1 year of age. The age specific rates were 46.0% in children age 1- < 3 years, 51.7% in children age 3- < 6 years, 54.8% in children age 6- < 9 years and 40.0% in children age 9- < 12 years. There was a significant difference in prevalence by gender; female 38.5% versus male 49.8% and by type of housing; permanent house 38.5% versus semi-permanent house 48.6%. Congestive living and education level of the female caretaker showed a clear trend for a difference in prevalence. Factors independently associated with Helicobacter pylori colonization included: drugs taken last three months, using a pit latrine, sources of drinking water and wealth index.Conclusion: The prevalence of Helicobacter pylori colonization among urban Ugandan children is high at an early age and increases with age. The impact of Helicobacter pylori colonization on children's health in Uganda needs to be further clarified. © 2010 Hestvik et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Hestvik, Elin
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Tylleskär, Thorkild
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Kaddu-Mulindwa, Deogratias H.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Ndeezi, Grace
Norway, Bergen
Universitetet I Bergen
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Grahnquist, Lena
Sweden, Stockholm
Karolinska Institutet
Olafsdottir, Edda
Norway, Bergen
Haukeland Universitetssjukehus
Tumwine, James Kashugyera
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Statistics
Citations: 89
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1186/1471-230X-10-62
e-ISSN:
1471230X
Research Areas
Environmental
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Uganda
Participants Gender
Male
Female