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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Analysis of the frequency of single nucleotide polymorphisms in cytokine genes in patients with New Onset Diabetes After Transplant
Scientific Reports, Volume 11, No. 1, Article 6014, Year 2021
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Description
New Onset Diabetes After Transplantation (NODAT) is a serious metabolic complication. While β-cell dysfunction is considered the main contributing factor in the development of NODAT, the precise pathogenesis is not well understood. Cytokines are thought to be involved in the inflammation of islet β-cells in diabetes; however, few studies have investigated this hypothesis in NODAT. A total of 309 kidney transplant recipients (KTRs) were included in this study. An association between kidney transplants, and the development of diabetes after transplant (NODAT) was investigated. Comparison was made between KTRs who develop diabetes (NODAT cases) or did not develop diabetes (control), using key cytokines, IL-6 G (− 174)C, macrophage mediator; IL-4 C (− 490)T, T helper (Th)-2 cytokine profile initiator; Th-1 cytokine profile initiator interferon-γ T (+ 874) A gene and TGF β1 C (+ 869) T gene polymorphisms were investigated. The genes were amplified using well-established polymerase chain reaction (PCR) techniques in our laboratory. Compared to the AA and AT genotypes of interferon gamma (IFNG), there was a strong association between the TT genotype of IFNG and NODAT kidney transplant recipients (KTRs) versus non-NODAT KTRs (p = 0.005). The AA genotype of IFNG was found to be predominant in the control group (p = 0.004). Also, significant variations of IL6 G (− 174) C, IL-4 C (− 590) T, interferon-γ T (+ 874) A gene and transforming growth factor β1 C (+ 869) T may contribute to NODAT. Our data is consistent with theTh-1/T-reg pathway of immunity. Further larger pan Arab studies are required to confirm our findings. © 2021, The Author(s).
Authors & Co-Authors
Jahromi, Mohamed Mirza
Kuwait, Dasman
Dasman Diabetes Institute
Bahrain, Manama
Sehatek Awal
Al-Otaibi, Torki
Kuwait, Safat
Ibn Sina Hospital Safat
Gheith, Osama Ashry Ahmed
Kuwait, Safat
Ibn Sina Hospital Safat
Egypt, Mansoura
Mansoura University
Farouk Othman, Nashwa
Egypt, Mansoura
Mansoura University
Kuwait, Dasman
Dasman Diabetes Institute
Mahmoud, Tarek S.H.
Kuwait, Safat
Ibn Sina Hospital Safat
Nair, Parasad
Kuwait, Safat
Ibn Sina Hospital Safat
A-Halim, Medhat
Kuwait, Safat
Ibn Sina Hospital Safat
Messenger, Grace
Kuwait, Dasman
Dasman Diabetes Institute
Chu, Philip
Bahrain, Manama
Sehatek Awal
De Serres, Sacha A.
Canada, Quebec
Université Laval
Azzi, Jamil R.
United States, Boston
Harvard Medical School
Statistics
Citations: 1
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1038/s41598-021-84400-9
ISSN:
20452322
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Randomised Control Trial