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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears
Cell, Volume 157, No. 4, Year 2014
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Description
Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyperlipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans. PaperClip © 2014 Elsevier Inc.
Authors & Co-Authors
Liu, Shiping
China, Shenzhen
Bgi-shenzhen
China, Guangzhou
South China University of Technology
Lorenzen, Eline Deirdre
United States, Berkeley
University of California, Berkeley
Denmark, Copenhagen
Statens Naturhistoriske Museum
Fumagalli, Matteo
United States, Berkeley
University of California, Berkeley
Li, Bo
China, Shenzhen
Bgi-shenzhen
Harris, Kelley
United States, Berkeley
University of California, Berkeley
Xiong, Zijun
China, Shenzhen
Bgi-shenzhen
Zhou, Long
China, Shenzhen
Bgi-shenzhen
Korneliussen, Thorfinn Sand
Denmark, Copenhagen
Statens Naturhistoriske Museum
Somel, Mehmet
United States, Berkeley
University of California, Berkeley
Turkey, Ankara
Middle East Technical University Metu
Babbitt, Courtney C.
United States, Durham
Duke University
United States, Amherst
University of Massachusetts Amherst
Wray, Gregory Allan
United States, Durham
Duke University
Li, Jianwen
China, Shenzhen
Bgi-shenzhen
He, Weiming
China, Shenzhen
Bgi-shenzhen
China, Guangzhou
South China University of Technology
Wang, Zhuo
China, Shenzhen
Bgi-shenzhen
Fu, Wenjing
China, Shenzhen
Bgi-shenzhen
Xiang, Xueyan
China, Shenzhen
Bgi-shenzhen
China, Chengdu
Sichuan University
Morgan, Claire C.
Ireland, Dublin
Dublin City University
Doherty, Aoife
Ireland, Maynooth
Maynooth University
O'Connell, Mary J.
Ireland, Dublin
Dublin City University
McInerney, James O.
Ireland, Maynooth
Maynooth University
Born, Erik Wolder
Greenland, Godthaab
Greenland Institute of Natural Resources
Dalèn, Love
Sweden, Stockholm
Naturhistoriska Riksmuseet
Dietz, Rune
Denmark, Aarhus
Aarhus Universitet
Orlando, Ludovic A.A.
Denmark, Copenhagen
Statens Naturhistoriske Museum
Sonne, Christian
Denmark, Aarhus
Aarhus Universitet
Zhang, Guojie
China, Shenzhen
Bgi-shenzhen
Denmark, Copenhagen
Københavns Universitet
Nielsen, Rasmus Wedel
China, Shenzhen
Bgi-shenzhen
United States, Berkeley
University of California, Berkeley
Denmark, Copenhagen
Københavns Universitet
Willerslev, Eske
Denmark, Copenhagen
Statens Naturhistoriske Museum
Wang, Jun
China, Shenzhen
Bgi-shenzhen
Denmark, Copenhagen
Københavns Universitet
Saudi Arabia, Jeddah
King Abdulaziz University
Macao, Taipa
Macau University of Science and Technology
Hong Kong, Hong Kong
The University of Hong Kong
Statistics
Citations: 345
Authors: 29
Affiliations: 17
Identifiers
Doi:
10.1016/j.cell.2014.03.054
ISSN:
00928674
e-ISSN:
10974172
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study