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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Antidiabetic effect of essential oil from Artemisia sieberi growing in Jordan in normal and alloxan induced diabetic rats
Pakistan Journal of Biological Sciences, Volume 13, No. 9, Year 2010
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Description
The aim of this study was to evaluate the effects of essential oil extracted from aerial parts of Artemisia sieberi in normal and alloxan induced diabetic rats. Fifty rats were divided into five groups of 10 each. Group I normal rats received 1 mL day-1 of dimethyl sulfoxide (control); group II normal rats received a single dose (80mg kg-1 b.wt.) of essential oil extract of Artemisia sieberi; group III diabetic rats received 1 mL day-1 of dimethyl sulfoxide; group IV diabetic rats received the oil extract (80 mg kg-1 b.wt.); group V diabetic rats received metformin (14.2 mg kg-1 b.wt.). All treatments were orally administered once a day for six weeks. Changes in blood glucose concentration, body weight and food and water intake were measured and the data obtained were compared with that of metformin. The essential oil extract significantly (p<0.05) lowered blood glucose level as well as food and water intake in diabetic rats accompanied by an increase in body weight gain with no apparent side effect when compared with untreated diabetic rats. These effects were found to be closely similar to that of metformin, a common antidiabetic drug. On other hand, no apparent improvement on body weight gain in diabetic rats treated with metformin. In addition, for all parameters measured, the oil extract showed no effect in normal rats. In conclusion, the essential oil of Artemisia sieberi exhibited antidiabetic activity in alloxan-induced diabetic rats. Present findings support the possible use of the essential oil of Artemisia sieberi as a remedy for diabetes mellitus in humans. © 2010 Asian Network for Scientific Information.
Authors & Co-Authors
Irshaid Irshaid, Fawzi
Jordan, Mafraq
Al Al-bayt University
Mansi, Kamal M.
Jordan, Mafraq
Al Al-bayt University
Aburjai, Talal
Jordan, Amman
The University of Jordan
Statistics
Citations: 26
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.3923/pjbs.2010.423.430
e-ISSN:
18125735
Research Areas
Environmental
Food Security
Noncommunicable Diseases