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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnosis and management of conjunctival and corneal intraepithelial neoplasia using ultra high-resolution optical coherence tomography
Ophthalmology, Volume 118, No. 8, Year 2011
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Description
Purpose: To report a novel diagnostic technique and a case series of conjunctival and corneal intraepithelial neoplasia (CCIN) diagnosed and followed up using prototype ultra high-resolution (UHR) optical coherence tomography (OCT). Design: Prospective, noncomparative, interventional case series. Participants: Seven eyes of 7 consecutive patients with CCIN treated using topical interferon alfa-2b or 5-fluorouracil and 7 eyes of 6 consecutive patients with history of surgically excised pterygia. Intervention: Ultra high-resolution OCT imaging of the ocular surface at primary diagnosis of CCIN and during the follow-up period until resolution of the lesion. Ultra high-resolution OCT images of sites of excised pterygia also were captured and compared with images from resolved CCIN patients. Main Outcome Measures: Clinical course and photographs, UHR OCT images, and histopathologic findings. Results: Ultra high-resolution OCT was capable of providing a noninvasive optical biopsy of all examined CCIN lesions. Ultra high-resolution OCT images of the lesions disclosed a thickened hyperreflective epithelium and abrupt transition from normal to hyperreflective epithelium in all 7 cases. Ultra high-resolution OCT images showed excellent correlation with histopathologic specimens obtained at primary diagnosis of the cases that had incisional biopsies before treatment. All patients were treated medically and were followed up for clinical resolution. In 4 patients, at clinical resolution, UHR OCT images also showed normal epithelial configuration at the site of the treated lesions. In 3 patients, despite apparent clinical resolution, the UHR OCT was able to detect residual disease that was clinically invisible. Continuation of treatment resulted in complete resolution of the residual lesions on the UHR OCT images in all cases. Ultra high-resolution OCT images of patients with surgically excised pterygia demonstrated similar findings to resolved CCIN cases. Conclusions: Ultra high-resolution OCT is a novel noninvasive technique to diagnose and manage medically treated CCIN. Using UHR OCT to guide medical treatment could prevent the premature termination of topical treatment in the presence of subclinical disease. A larger sample size is needed for further validation of its sensitivity and specificity. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2011 American Academy of Ophthalmology.
Authors & Co-Authors
Shousha, Mohamed Abou
United States, Miami
Bascom Palmer Eye Institute
Egypt, Alexandria
Faculty of Medicine
Karp, Carol Lynn
United States, Miami
Bascom Palmer Eye Institute
Perez, Victor L.
United States, Miami
Bascom Palmer Eye Institute
Hoffmann, Rodrigo
United States, Miami
Bascom Palmer Eye Institute
Ventura, Roberta
United States, Miami
Bascom Palmer Eye Institute
Chang, Victoria
United States, Miami
Bascom Palmer Eye Institute
Dubovy, Sander R.
United States, Miami
Bascom Palmer Eye Institute
United States, Miami
Florida Lions Ocular Pathology Laboratory
Wang, Jianhua
United States, Miami
Bascom Palmer Eye Institute
Statistics
Citations: 95
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.ophtha.2011.01.005
e-ISSN:
15494713
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Randomised Control Trial
Cohort Study