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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
An open clinical trial of nifurtimox for arseno-resistant trypanosoma brucei gambiense sleeping sickness in central zaire
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 83, No. 4, Year 1989
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Description
Twenty-five patients with arseno-resistant Trypanosoma brucei gambiense sleeping sickness were treated with oral nifurtimox, 12-17 mg/kg/d for 60 d. During treatment, trypanosomes disappeared from the cerebrospinal fluid (CSF) of 7/7 patients; the CSF infections; leucocyte was significantly lower at the end of treatment than before it was begun (pre-nifurti- mox: 124.2 (± 149.3) per μl; post-nifurtimox: 11.9 (±12-1) per μl; P<0.001). Nifurtimox was well tolerated, with gastro-intestinal disturbances in 6 patients and a reversible cerebellar syndrome in 2 patients. Among the 19 patients seen at least once at follow-up, 12 (63%) relapsed. The other 7 patients have been followed for 3-18 months, and the CSF remained completely normal in 4 of them. This study confirms that nifurtimox has some activity against T.b. gambiense, but a daily dosage higher than 15 mg/kg/d will be necessary to achieve cure of most patients. © Oxford University Press.
Authors & Co-Authors
Pépin, Jacques
Senegal
Mrc Labratories
Milord, François
Canada, Sherbrooke
Université de Sherbrooke
Éthier, Lucien
Canada, Sherbrooke
Université de Sherbrooke
Ethier, L.
Canada
Zone de Santé Rurale de Nioki
Milord, F.
Canada
Zone de Santé Rurale de Nioki
Mpia, Bokelo
Canada
Zone de Santé Rurale de Nioki
Meurice, F.
United Kingdom
Hôpital de Mushie
Degroof, D.
United Kingdom
Hôpital de Bagata
Bruneel, Herman
United Kingdom
Hôpital de Bagata
Statistics
Citations: 59
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/0035-9203(89)90270-8
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Health System And Policy
Study Design
Cohort Study