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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
High prevalence of Methicillin resistant Staphylococcus aureus in the surgical units of Mulago hospital in Kampala, Uganda
BMC Research Notes, Volume 4, Article 326, Year 2011
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Description
Background: There is limited data on Methicillin resistant Staphylococcus aureus (MRSA) in Uganda where, as in most low income countries, the routine use of chromogenic agar for MRSA detection is not affordable. We aimed to determine MRSA prevalence among patients, healthcare workers (HCW) and the environment in the burns units at Mulago hospital, and compare the performance of CHROMagar with oxacillin for detection of MRSA. Results: One hundred samples (from 25 patients; 36 HCW; and 39 from the environment, one sample per person/item) were cultured for the isolation of Staphylococcus aureus. Forty one S. aureus isolates were recovered from 13 patients, 13 HCW and 15 from the environment, all of which were oxacillin resistant and mecA/femA/nuc-positive. MRSA prevalence was 46% (41/89) among patients, HCW and the environment, and 100% (41/41) among the isolates. For CHROMagar, MRSA prevalence was 29% (26/89) among patients, HCW and the environment, and 63% (26/41) among the isolates. There was high prevalence of multidrug resistant isolates, which concomitantly possessed virulence and antimicrobial resistance determinants, notably biofilms, hemolysins, toxin and ica genes. One isolate positive for all determinants possessed the bhp homologue which encodes the biofilm associated protein (BAP), a rare finding in human isolates. SCCmec type I was the most common at 54% prevalence (22/41), followed by SCCmec type V (15%, 6/41) and SCCmec type IV (7%, 3/41). SCCmec types II and III were not detected and 10 isolates (24%) were non-typeable. Conclusions: Hyper-virulent methicillin resistant Staphylococcus aureus is prevalent in the burns unit of Mulago hospital. © 2011 Najjuka et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3184088/bin/1756-0500-4-326-S1.DOC
https://efashare.b-cdn.net/share/pmc/articles/PMC3184088/bin/1756-0500-4-326-S2.XLS
Authors & Co-Authors
Kateete, David Patrick
Uganda, Kampala
Makerere University College of Health Sciences
Namazzi, Sylvia
Uganda, Kampala
Makerere University College of Health Sciences
Uganda, Kampala
Makerere University
Okee, Moses S.
Uganda, Kampala
Makerere University College of Health Sciences
Okeng, Alfred
Uganda, Kampala
Makerere University College of Health Sciences
Baluku, Hannington
Uganda, Kampala
Makerere University College of Health Sciences
Musisi, N.
Uganda, Kampala
Makerere University
Katabazi, Fred Ashaba
Uganda, Kampala
Makerere University College of Health Sciences
Joloba, Moses Lutaakome
Uganda, Kampala
Makerere University College of Health Sciences
Ssentongo, Robert
Uganda, Kampala
Mulago National Referral Hospital
Najjuka, Florence C.
Uganda, Kampala
Makerere University College of Health Sciences
Statistics
Citations: 76
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1186/1756-0500-4-326
Research Areas
Health System And Policy
Violence And Injury
Study Design
Cross Sectional Study
Study Locations
Uganda