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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA, and HPT axes in zebrafish
Environmental Science and Technology, Volume 45, No. 2, Year 2011
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Description
The objective of this study was to assess chemical-induced effects on cross-talk among the hypothalamic-pituitary-gonad (HPG), hypothalamic-pituitary- adrenal (HPA), and hypothalamic-pituitary-thyroid (HPT) axes of fish. Adult female zebrafish were exposed to 300 μg/L prochloraz (PCZ) or 100 mg/L propylthiouracil (PTU), and the transcriptional profiles of the HPG, HPA, and HPT axes were examined. Exposure to PCZ decreased plasma testosterone (T) and 17β-estradiol (E2) concentrations and affected HPA and HPT axes by down-regulating corticotrophin-releasing hormone (CRH) after 12 and 48 h. By using correlation analyses, it was found that the decrease in E2 plasma concentrations caused by PCZ was correlated with the down-regulation of CRH mRNA expression. Exposure to PTU resulted in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 and 48 h. Concentrations of FSH and LH were negatively correlated with concentrations of T4 and T3. These results are consistent with the hypothesis that increased steroidogenic gene expression after PTU exposure resulted from a reduction in T4 and T3 concentrations, which resulted in greater secretion of FSH and LH. © 2011 American Chemical Society.
Authors & Co-Authors
Liu, Chunsheng
China, Wuhan
Institute of Hydrobiology, Chinese Academy of Sciences
Zhang, Xiaowei
China, Nanjing
Nanjing University
Deng, Jun
China, Wuhan
Institute of Hydrobiology, Chinese Academy of Sciences
Hecker, Markus
United States, Houston
Entrix Inc.
Al-Khedhairy, Abdulaziz Ali A.
Saudi Arabia, Riyadh
College of Sciences
Giesy, John P.
Canada, Saskatoon
University of Saskatchewan
Zhou, Bingsheng
China, Wuhan
Institute of Hydrobiology, Chinese Academy of Sciences
Statistics
Citations: 117
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1021/es102659p
ISSN:
0013936X
e-ISSN:
15205851
Research Areas
Genetics And Genomics
Participants Gender
Female