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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Juvenile nasopharyngeal carcinoma: Anatomoclinic, biologic, therapeutic and evolutive aspects
Bulletin du Cancer, Volume 97, No. 4, Year 2010
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Description
Nasopharyngeal carcinoma (NPC) represents one of the most frequent epithelial tumours of the child in intermediate risk regions. In the Maghreb, it represents the first cancer of teenagers of 15-20 years old. The Epstein Barr virus (EBV) is the most important etiologic factor. Its role in the pathogeneses of NPC has been confirmed by several studies. Young NPCs are characterized by a low rate of EBV antibodies and a high level of LMP1 cell expression than in adult's NPC. The undifferentiated carcinoma nasopharyngeal type (UCNT) represents the most frequent histological type. Immunohistochimical analyses of North Africa early onset NPC is characterized by a weak expression of bcl-2 and p53 and a strong expression of LMP1 and c-kit what makes them different from the adult's NPC. Clinically, cervical node involvement is constantly present. Juvenile NPC is characterized by a very important locoregional extension as well as a high rate of distant metastases. More than 15% of patients had metastases at diagnosis. Radiotherapy is still the standard therapy of NPC. Only some retrospectives studies have been published to determine the benefit, the type and the timing of the chemotherapy in the treatment of juvenile NPC. Metastatic relapses constitute the main cause of death at these young patients. An improvement of the prognosis can be waited with concomitant chemotherapy and intensity modulated radiotherapy. However, randomized multi institutional studies are necessary to standardize the treatment of the NPC in childhood. ©John Libbey Eurotext.
Authors & Co-Authors
Toumi, Nabil
Tunisia, Sfax
Chu Habib Bourguiba
Frikha, Mounir F.
Tunisia, Sfax
Chu Habib Bourguiba
Tunisia
Arome Association de Radiothérapie et D'oncologie de la Méditerranée
Siala, Wissem
Tunisia, Sfax
Chu Habib Bourguiba
Khabir, Abdelmajid
Tunisia, Sfax
Chu Habib Bourguiba
Karray, Héla H.
Tunisia, Sfax
Chu Habib Bourguiba
Sellami-Boudawara, Tahiya
Tunisia, Sfax
Chu Habib Bourguiba
Mokded Gargouri, R.
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Tunisia
Arome Association de Radiothérapie et D'oncologie de la Méditerranée
Ghorbel, Monem
Tunisia, Sfax
Chu Habib Bourguiba
Daoud, Jamel L.
Tunisia, Sfax
Chu Habib Bourguiba
Tunisia
Arome Association de Radiothérapie et D'oncologie de la Méditerranée
Statistics
Citations: 9
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1684/bdc.2010.1087
ISSN:
00074551
e-ISSN:
17696917
Research Areas
Cancer
Maternal And Child Health
Study Locations
Multi-countries