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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The Endothelium: A Key to the Future
Journal of Cardiac Surgery, Volume 8, No. 1, Year 1993
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Description
The vascular endothelium is a complex modulator of a variety of biological systems and may well be the key to definitive success in the treatment of cardiovascular disorders. Surgically‐induced endothelial injury may occur preoperatively during cardiac catheterization and intraoperatively from mechanical manipulation, ischemia, hypothermia, and exposure to cardio‐plegic solutions. The normal endothelium is antithrombogenic and yet promotes platelet aggregation and coagulation if injured. Vasospasm, occlusive intimal hyperplasia, and accelerated arteriosclerosis can also all occur as a result of endothelial injury. Furthermore, endothelial injury is harmful even in the absence of disruption of its monolayer integrity. Thus, preservation of the endothelium should be an additional objective for all cardiovascular surgeons. Synthetic vascular grafts, cardiac valves, and artificial ventricles do not spontaneously endothelialize and thus usually require some form of anticoagulation to maintain patency. Hence, endothelialization of prosthetic implants became an attractive concept. A number of different methods of obtaining an endothelial lining of prosthetic material has since been developed; these include facilitated endothelial cell migration, and endothelial cell seeding by using either venous or microvascular endothelial cells. Manipulating the endothelium might well provide the next major advancement for therapeutic and preventative measures for cardiovascular disease. Copyright © 1993, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Zilla, Peter P.
South Africa, Cape Town
University of Cape Town
Von-Oppell, Ulrich Otto
South Africa, Cape Town
University of Cape Town
Deutsch, Manfred
Austria, Vienna
Allgemeines Krankenhaus Wien
Statistics
Citations: 118
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1111/j.1540-8191.1993.tb00574.x
e-ISSN:
15408191
Research Areas
Noncommunicable Diseases
Violence And Injury