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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Subunit recombinant vaccine protects against monkeypox
Journal of Immunology, Volume 177, No. 4, Year 2006
Notification
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Description
The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. Because Abs to VACV mediate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine able to induce a protective Ab response. We immunized rhesus macaques with plasmid DNA encoding the monkeypox orthologs of the VACV L1R, A27L, A33R, and B5R proteins by the intradermal and i.m. routes, either alone or in combination with the equivalent recombinant proteins produced in Escherichia coli. Animals that received only DNA failed to produce high titer Abs, developed innumerable skin lesions after challenge, and died in a manner similar to placebo controls. By contrast, the animals vaccinated with proteins developed moderate to severe disease (20-155 skin lesions) but survived. Importantly, those immunized with DNA and boosted with proteins had mild disease with 15 or fewer lesions that resolved within days. DNA/protein immunization elicited Th responses and binding Ab titers to all four proteins that correlated negatively with the total lesion number. The sera of the immunized macaques recognized a limited number of linear B cell epitopes that are highly conserved among orthopoxviruses. Their identification may guide future efforts to develop simpler, safer, and more effective vaccines for monkeypox and smallpox. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Héraud, Jean Michel
United States, Rockville
National Cancer Institute Nci
Kalyanaraman, Vaniambadi S.
United States, Kensington
Advanced Bioscience Laboratories, Inc.
Hryniewicz, Anna
United States, Rockville
National Cancer Institute Nci
Poland, Bialystok
Uniwersytet Medyczny w Bialymstoku
Trindade, Christopher Julius
United States, Rockville
National Cancer Institute Nci
Tsai, Wenpo
United States, Rockville
National Cancer Institute Nci
Venzon, David J.
United States, Rockville
National Cancer Institute Nci
Vaccari, Monica
United States, Rockville
National Cancer Institute Nci
Silvera, Peter M.
United States, Birmingham
Southern Research
Graham, Barney S.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Golding, Hana A.
United States, Silver Spring
Food and Drug Administration
Hooper, Jay Williams
United States, Fort Detrick
U.s. Army Medical Research Institute of Infectious Diseases
Franchini, Genoveffa
United States, Rockville
National Cancer Institute Nci
Statistics
Citations: 121
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.4049/jimmunol.177.4.2552
ISSN:
00221767
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health