Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Adult T-cell leukemia/lymphoma in HTLV-1 non-endemic regions
Journal of Clinical Virology, Volume 167, Article 105578, Year 2023
Notification
URL copied to clipboard!
Description
Background: HTLV-1 infection is a neglected disease, despite producing neurological and lymphoproliferative severe illnesses and affect over 10 million people worldwide. Roughly 5% of HTLV-1 carriers develop Adult T-cell leukemia/lymphoma (ATLL), one of the most aggressive hematological malignancies. Methods: A national HTLV-1 register exists since 1989 in Spain, a non-endemic country with a large migrant flow from Latin America and Equatorial Africa, where HTLV-1 is endemic. The main features of all patients diagnosed with ATLL in Spain up to date are reported. Results: A total of 451 cases of HTLV-1 infection had been reported in Spain until the end of year 2022. ATLL had been diagnosed in 35 (7.8%). The current average incidence of ATLL in Spain is of two cases per year. Women represent 57% of ATLL patients. Mean age at diagnosis was 47 years-old. Roughly 57% were Latin Americans and 26% Africans. At diagnosis, the majority presented with acute or lymphoma clinical forms. Survival was shorter than one year in most of them. Mean HTLV-1 proviral load was significantly greater in ATLL patients than in asymptomatic HTLV-1 carriers (2,305 vs 104 copies/104 PBMC). HTLV-1 subtyping in 6 ATLL patients found the 1a transcontinental variant (n = 4) and the Japanese variant (n = 2). All ATLL patients were negative for HIV-1, did not develop HTLV-1-associated myelopathy and were not transplant recipients. Conclusion: The rate of ATLL is very low in Spain and mostly associated to migrants from HTLV-1 endemic regions. Given the poor clinical outcome of ATLL, HTLV-1 testing should be performed at least once in all migrants coming from HTLV-1 endemic countries and in natives who have lived in or had sex partners from such regions. © 2023 Elsevier B.V.
Authors & Co-Authors
de-Mendoza, Carmen
Spain, Majadahonda
Hospital Universitario Puerta de Hierro Majadahonda
Miró, Elisenda
Spain, Barcelona
Hospital de la Santa Creu I Sant Pau
Reina, G.
Spain, Pamplona
Universidad de Navarra
Pintos, Ilduara
Spain, Majadahonda
Hospital Universitario Puerta de Hierro Majadahonda
Soriano, Vicente Vicente
Spain, Logrono
International University of la Rioja
Iglesias, M. A.R.
Spain, Cadiz
Hospital Universitario Puerta Del Mar
García, Federico Alcacer
Spain, Granada
Hospital Universitario San Cecilio
Benito, R.
Spain, Zaragoza
Hospital Clinico Universitario Lozano Blesa
Algarate, S.
Spain, Zaragoza
Hospital Clinico Universitario Lozano Blesa
Mellado-Peña, María José
Unknown Affiliation
Cano, María Eliecer
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Aguilera, Antonio
Unknown Affiliation
García, Juan González
Unknown Affiliation
Ramos-Rincón, José Manuel
Spain, Alicante
Hospital General Universitario de Alicante
Sauleda, Sílvia
Spain, Barcelona
Banco de Sangre y Tejidos de Cataluña
Pirón, María
Spain, Barcelona
Banco de Sangre y Tejidos de Cataluña
Rodríguez, Carmen
Unknown Affiliation
del Romero, Jorge D.
Unknown Affiliation
Fernández-Ruiz, Mario
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas
Barreiro, Pablo M.
Unknown Affiliation
Corral-Pazos de Provens, Octavio Jorge
Spain, Logrono
International University of la Rioja
Moreno-Torres, Victor
Spain, Majadahonda
Hospital Universitario Puerta de Hierro Majadahonda
Statistics
Authors: 22
Affiliations: 39
Identifiers
Doi:
10.1016/j.jcv.2023.105578
ISSN:
13866532
Research Areas
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Female