Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Relationship Between B-Vitamin Biomarkers and Dietary Intake with Apolipoprotein E є4 in Alzheimer’s Disease
Journal of Nutrition in Gerontology and Geriatrics, Year 2019
Notification
URL copied to clipboard!
Description
The potential for B-vitamins to reduce plasma homocysteine (Hcy) and reduce the risk of Alzheimer’s disease (AD) has been described previously. However, the role of Apolipoprotein E є4 (APOE4) in this relationship has not been adequately addressed. This case-control study explored APOE4 genotype in an Australian sample of 63 healthy individuals (female = 38; age = 76.9 ± 4.7 y) and 63 individuals with AD (female = 35, age = 77.1 ± 5.3 y). Findings revealed 55 of 126 participants expressed the APOE4 genotype with 37 of 126 having both AD and the APOE4 genotype. Analysis revealed an increased likelihood of AD when Hcy levels are >11.0 µmol/L (p = 0.012), cysteine levels were <255 µmol/L (p = 0.033) and serum folate was <22.0 nmol/L (p = 0.003; in males only). In females, dietary intake of total folate <336 µg/day (p=0.001), natural folate <270 µg/day (p = 0.011), and vitamin B2 < 1.12 mg/day (p = 0.028) was associated with an increased AD risk. These results support Hcy, Cys, and SF as useful biomarkers for AD, irrespective of APOE4 genotype and as such should be considered as part of screening and managing risk of AD. © 2019, © 2019 Taylor & Francis Group, LLC.
Authors & Co-Authors
D'Cunha, Nathan M.
Australia, Canberra
University of Canberra
Australia, Canberra
Collaborative Research in Bioactives and Biomarkers Cribb Group
Georgousopoulou, Ekavi N.
Australia, Canberra
University of Canberra
Australia, Canberra
Collaborative Research in Bioactives and Biomarkers Cribb Group
Greece, Athens
Harokopio University of Athens
McKune, Andrew J.
Australia, Canberra
University of Canberra
Australia, Canberra
Collaborative Research in Bioactives and Biomarkers Cribb Group
Mellor, Duane D.
Australia, Canberra
University of Canberra
Australia, Canberra
Collaborative Research in Bioactives and Biomarkers Cribb Group
United Kingdom, Coventry
Faculty of Science, Engineering and Medicine
Roach, Paul D.
Australia, Callaghan
The University of Newcastle, Australia
Naumovski, Nenad
Australia, Canberra
University of Canberra
Australia, Canberra
Collaborative Research in Bioactives and Biomarkers Cribb Group
Australia, Callaghan
The University of Newcastle, Australia
Statistics
Citations: 9
Authors: 6
Affiliations: 7
Identifiers
Doi:
10.1080/21551197.2019.1590287
ISSN:
21551197
Research Areas
Genetics And Genomics
Study Design
Case-Control Study
Participants Gender
Female