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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association between age at antiretroviral therapy initiation and 24-month immune response in West-African HIV-infected children
AIDS, Volume 28, No. 11, Year 2014
Notification
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Description
Objective: We describe the association between age at antiretroviral therapy (ART) initiation and 24-month CD4+ cell response in West African HIV-infected children. Methods: All HIV-infected children from the IeDEA paediatric West African cohort, initiating ART, with at least two CD4+ cell count measurements, including one at ART initiation (baseline) were included. CD4+ cell gain on ART was estimated using a multivariable linear mixed model adjusted for baseline variables: age, CD4+ cell count, sex, first-line ARTregimen. Kaplan-Meier survival curves and a Cox proportional hazards regression model compared immune recovery for age within 24 months post-ART. Results: Of the 4808 children initiated on ART, 3014 were enrolled at a median age of 5.6 years; 61.2% were immunodeficient. After 12 months, children at least 4 years at baseline had significantly lower CD4+ cell gains compared with children less than 2 years, the reference group (P<0.001). However, by 24 months, we observed higher CD4+ cell gain in children who initiated ART between 3 and 4 years compared with those less than 2 years (P<0.001). The 24-month CD4+ cell gain was also strongest in immunodeficient children at baseline. Among these children, 75% reached immune recovery: 12-month rates were significantly highest in all those aged 2-5 years at ART initiation compared with those less than 2 years. Beyond 12 months on ART, immune recovery was significantly lower in children initiated more than 5 years (adjusted hazard ratio: 0.69, 95% confidence interval: 0.56-0.86). Conclusion: These results suggest that both the initiation of ART at the earliest age less than 5 years and before any severe immunodeficiency is needed for improving 24-month immune recovery on ART. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Desmonde, Sophie
France, Paris
Inserm
Dicko-Traoré, Fatoumata B.
Mali, Bamako
Hopital Gabriel Toure
Nigeria
Ch Gabriel Toure
Kouéta, Fla
Burkina Faso, Ouagadougou
Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Eboua, Tanoh Kassi François
Cote D'ivoire
Centre Hospitalo-universitaire de Yopougon
Balestre, Eric
France, Paris
Inserm
Amani-Bossé, Clarisse
Cote D'ivoire, Abidjan
Programme Mtct+
Aka, Edmond Addi
Cote D'ivoire, Abidjan
De Recherche et de Formation Cepref
Cote D'ivoire
Aconda-cepref
Lawson-Évi, Koko
Togo, Lome
Centre Hospitalier Universitaire Tokoin
Togo
Chu Tokoin/sylvanus Olympio
Amorissani-Folquet, Madeleine
Cote D'ivoire
Centre Hospitalo-universitaire de Cocody
Kouakou, Kouadio P.
Cote D'ivoire, Abidjan
Cirba
Koumakpaï, Sikiratou
Benin, Cotonou
Centre National Hospitalier Universitaire Hubert Koutoukou Maga
A Renner, Lorna
Ghana, Accra
Korle bu Hospital
Ghana
Korle bu th
Signaté-Sy, Haby
Senegal, Dakar
Hôpital Des Enfants Albert Royer
Leroy, Valeriane
France, Paris
Inserm
Zannou, Djimon Marcel
Burkina Faso
Cnhu Hubert Maga
Ahouada, Carin
Burkina Faso
Cnhu Hubert Maga
Akakpo, Jocelyn
Burkina Faso
Cnhu Hubert Maga
Ahomadégbé, Christelle
Burkina Faso
Cnhu Hubert Maga
Bashi, Jules B.
Burkina Faso
Cnhu Hubert Maga
Gougounon-Houêto, Alice
Burkina Faso
Cnhu Hubert Maga
Azon-Kouanou, Angèle
Burkina Faso
Cnhu Hubert Maga
Houngbè, Fabien
Burkina Faso
Cnhu Hubert Maga
Séhonou, Jean J.
Burkina Faso
Cnhu Hubert Maga
Koumakpaï, Sikiratou A.
Burkina Faso
Cnhu Hubert Maga
Alihonou, Florence
Burkina Faso
Cnhu Hubert Maga
D'Almeida, Marcelline
Burkina Faso
Cnhu Hubert Maga
Hodonou, Irvine
Burkina Faso
Cnhu Hubert Maga
Hounhoui, Ghislaine
Burkina Faso
Cnhu Hubert Maga
Sagbo, Gracien
Burkina Faso
Cnhu Hubert Maga
Tossa-Bagnan, Leïla
Burkina Faso
Cnhu Hubert Maga
Adjide, Herman
Burkina Faso
Cnhu Hubert Maga
Drabo, Joseph Youssouf
Burkina Faso, Ouagadougou
Chu Yalgado
Bognounou, René
Burkina Faso, Ouagadougou
Chu Yalgado
Diendéré, Arnaud Eric
Burkina Faso, Ouagadougou
Chu Yalgado
Traore, Eliezer
Burkina Faso, Ouagadougou
Chu Yalgado
Zoungrana, Lassané A.
Burkina Faso, Ouagadougou
Chu Yalgado
Zerbo, Béatrice
Burkina Faso, Ouagadougou
Chu Yalgado
Sawadogo, Adrien Bruno
Burkina Faso
Chu Souro Sanou
Zoungrana, Jacques
Burkina Faso
Chu Souro Sanou
Héma, Arsène
Burkina Faso
Chu Souro Sanou
Soré, Ibrahim
Burkina Faso
Chu Souro Sanou
Bado, Guillaume
Burkina Faso
Chu Souro Sanou
Tapsoba, Achille
Burkina Faso
Chu Souro Sanou
Yé, Diarra
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Ouédraogo, Sylvie Armelle P.
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Ouédraogo-Traoré, Rasmata
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Hiembo, William
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Gansonré, Mady
Burkina Faso, Ouagadougou
Charles de Gaulle Pediatric University Hospital
Messou, Eugéne
Burkina Faso
Aconda-cepref
Gnokoro, Joachim Charles
Burkina Faso
Aconda-cepref
Koné, Mamadou
Burkina Faso
Aconda-cepref
Kouakou, Guillaume Martial
Burkina Faso
Aconda-cepref
Bosse, Clarisse Amani
Burkina Faso
Aconda-mtct-plus
Brou, Kouakou J.
Burkina Faso
Aconda-mtct-plus
Assi, Achi Isidore
Burkina Faso
Aconda-mtct-plus
Chenal, Henri
Cote D'ivoire, Abidjan
Cirba
Hawerlander, Denise
Cote D'ivoire, Abidjan
Cirba
Soppi, Franck
Cote D'ivoire, Abidjan
Cirba
Minga, Albert Kla
Cote D'ivoire, Abidjan
Cmsds/cnts
Abo, Yao
Cote D'ivoire, Abidjan
Cmsds/cnts
Yoboue, Jean Michel
Cote D'ivoire, Abidjan
Cmsds/cnts
Eholié, Serge Paul
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Amego, Mensah Deborah Noelly
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Andavi, Viviane
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Diallo, Zélica
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Ello, Frêdéric Nogbou
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Tanon, Aristophane Koffi
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Koulé, Serge Olivier
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Anzan, Koffi Charles
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Guéhi, Calixte
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Issouf, Koffi Ladji
Cote D'ivoire
Aconda-cepref
Kouakou, Jean Claude
Cote D'ivoire
Aconda-cepref
N'Gbeche, Marie Sylvie
Cote D'ivoire
Aconda-cepref
Pety, Touré
Cote D'ivoire
Aconda-mtct-plus
Avit-Edi, Divine
Cote D'ivoire
Aconda-mtct-plus
Moh, Magloire
Cote D'ivoire, Abidjan
Cirba
Yao, Valérie Andoblé
Cote D'ivoire, Abidjan
Cirba
Folquet, Madeleine Amorissani
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Dainguy, Marie Evelyne
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Kouakou, Cyrille
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Méa-Assandé, Véronique Tanoh
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Oka-Bérété, Gladys
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Zobo, Nathalie
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Acquah, Patrick
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Kokora, Marie Berthe
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Eboua, Tanoh François
Cote D'ivoire
Chu Yopougon
Timité-Konan, Marguerite
Cote D'ivoire
Chu Yopougon
Ahoussou, Lucrèce Diecket
Cote D'ivoire
Chu Yopougon
Assouan, Julie Kebé
Cote D'ivoire
Chu Yopougon
Sami, Mabéa Flora
Cote D'ivoire
Chu Yopougon
Kouadio, Clémence
Cote D'ivoire
Chu Yopougon
Goka, Bamenla Quarm
Ghana
Korle bu th
Welbeck, Jennifer E.
Ghana
Korle bu th
Sackey, Adziri Harold
Ghana
Korle bu th
Owiafe, Seth Ntiri
Ghana
Korle bu th
Wejse, Christian
Guinea-bissau, Bissau
Bandim Health Project
da Silva, Zacarias José
Guinea-bissau, Bissau
Bandim Health Project
Paulo, Joao
Guinea-bissau, Bissau
Bandim Health Project
Rodrigues, Amabélia
Guinea-bissau, Bissau
Bandim Health Project
da Silva, David
Guinea-bissau, Bissau
National Hiv Program Bissau
Medina, Candida
Guinea-bissau
Hospital National Simao Mendes
Oliviera-Souto, Ines
Guinea-bissau, Bissau
Bandim Health Project
Østergaard, Lars Jørgen
Denmark, Aarhus
Aarhus Universitetshospital
Laursen, Alex Lund
Denmark, Aarhus
Aarhus Universitetshospital
Sodemann, Morten
Denmark, Odense
Odense Universitetshospital
Aaby, Peter
Guinea-bissau, Bissau
Bandim Health Project
Fomsgaard, Anders
Denmark, Copenhagen
Statens Serum Institut
Erikstrup, Christian
Unknown Affiliation
Eugen-Olsen, Jesper
Denmark, Hvidovre
Hvidovre Hospital
Maïga, Moussa Youssouffa
Nigeria
Ch Gabriel Toure
Kallé, Abdoulaye
Nigeria
Ch Gabriel Toure
Katilé, Drissa
Nigeria
Ch Gabriel Toure
Traoré, Hammar Alassane
Nigeria
Ch Point g
Minta, Daouada K.
Nigeria
Ch Point g
Cissé, Tidiani
Nigeria
Ch Point g
Dembélé, Mamadou Y.
Nigeria
Ch Point g
Fomba, Mahamadou
Nigeria
Ch Point g
Kaya, Assêtou Soukho
Nigeria
Ch Point g
Traoré, Abdoulaye Mamadou
Nigeria
Ch Point g
Traoré, Hamady H.
Nigeria
Ch Point g
Touré, Amadou Abathina
Nigeria
Ch Point g
Sylla, Mariam Moustapha
Nigeria
Ch Gabriel Toure
Koné, Niaboula
Nigeria
Ch Gabriel Toure
N'Diaye, Clémentine
Nigeria
Ch Gabriel Toure
Traoré, Mamadou M.
Nigeria
Ch Gabriel Toure
Charurat, Man
Unknown Affiliation
Ajayi, Samuel Oluwole
Nigeria, Abuja
Uath
Dapiap, Stephen B.
Nigeria, Abuja
Uath
Igbinoba, Festus
Nigeria, Abuja
National Hospital, Abuja
Benson, Okwara
Nigeria, Benin
Ubth
Adebamowo, Clement
Nigeria, Benin
Ubth
Seydi, Moussa
Senegal
Chu Fann
Sow, Papa Salif
Senegal
Chu Fann
Diop, Bernard Marcel
Senegal
Chu Fann
Manga, Noël Magloire
Senegal
Chu Fann
Tine, Judicaël Malick
Senegal
Chu Fann
Bassabi, Coumba Cissé
Senegal
Chu Fann
Sy, Haby Signaté
Unknown Affiliation
Ba, Abou
Unknown Affiliation
Dior, Hélène
Unknown Affiliation
Faye, Malick L.
Unknown Affiliation
Gueye, Ramatoulaye Diagne
Unknown Affiliation
Mbaye, Aminata Diack
Unknown Affiliation
Patassi, Akouda Akessiwe
Togo
Chu Tokoin/sylvanus Olympio
Kotosso, Awerou
Togo
Chu Tokoin/sylvanus Olympio
Gbadamassi, Gafarou
Togo
Chu Tokoin/sylvanus Olympio
Atakouma, Yawo Dzayissè
Togo
Chu Tokoin/sylvanus Olympio
Takassi, Elom Ounoo
Togo
Chu Tokoin/sylvanus Olympio
Dabis, Franćois Ç.Ois
France, Paris
Inserm
Bissagnéné, Emmanuel
France, Paris
Inserm
Arrivé, Élise
France, Paris
Inserm
Coffié, Patrick Ahuatchi
Cote D'ivoire, Abidjan
Cirba
Ékouévi, Didier Koumavi
Cote D'ivoire, Abidjan
Cirba
Jaquet, Antoine
France, Paris
Inserm
Lewden, Charlotte
France, Paris
Inserm
Sasco, Annie Jeanne
France, Paris
Inserm
Amani, Dieudonné
Cote D'ivoire, Abidjan
Cirba
Azani, Jean Claude
Cote D'ivoire, Abidjan
Cirba
Bessekon, Serge
Cote D'ivoire, Abidjan
Cirba
Bohossou, Franck
Cote D'ivoire, Abidjan
Cirba
Gilbert, Camille
France, Paris
Inserm
Karcher, Sophie
France, Paris
Inserm
Gonsan, Jules Mahan
Cote D'ivoire, Abidjan
Cirba
Le Carrou, Jérôme
France, Paris
Inserm
Lenaud, Sêverin
Cote D'ivoire, Abidjan
Cirba
Nchot, Célestin
Cote D'ivoire, Abidjan
Cirba
Malateste, Karen
France, Paris
Inserm
Siloué, Bertine
Cote D'ivoire, Abidjan
Cirba
Doring, Alexandra
France, Paris
Inserm
Kouakou, Adrienne V.
Cote D'ivoire, Abidjan
Cirba
Rabourdin, Elodie
France, Paris
Inserm
Anglaret, Xavier
France, Paris
Inserm
Ba, Boubacar
Mali, Bamako
Hopital Gabriel Toure
Becquet, Renaud
France, Paris
Inserm
Essanin, Jean Bosco
Cote D'ivoire, Abidjan
De Recherche et de Formation Cepref
Ciaranello, Andrea L.
Unknown Affiliation
Datté, Sébastien Atta
Cote D'ivoire, Abidjan
Cirba
Diby, Jean Serge Elvis
Cote D'ivoire, Abidjan
Cirba
Gottlieb., Geoffrey S.
Unknown Affiliation
Horo, Apollinaire Gninlgninrin
Cote D'ivoire, Abidjan
Cirba
Malvy, Denis Jean Marie
France, Paris
Inserm
Meless, David Guanga
Cote D'ivoire, Abidjan
Cirba
Mounkaila-Harouna, Aïda
France, Paris
Inserm
Ndondoki, Camille
France, Paris
Inserm
Shiboski, Caroline H.
Unknown Affiliation
Tchounga, Boris Kévin
Cote D'ivoire, Abidjan
Cirba
Thíébaut, Rodolphe
France, Paris
Inserm
Wandeler, Gilles
Senegal, Dakar
Hôpital Des Enfants Albert Royer
Statistics
Citations: 13
Authors: 188
Affiliations: 40
Identifiers
Doi:
10.1097/QAD.0000000000000272
ISSN:
02699370
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study