Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efficacy and safety of fluvastatin in children and adolescents with heterozygous familial hypercholesterolaemia
Acta Paediatrica, International Journal of Paediatrics, Volume 95, No. 11, Year 2006
Notification
URL copied to clipboard!
Description
Aim: To assess whether early initiation of statin therapy for heterozygous familial hypercholesterolaemia favourably affects lipid profiles or vascular morphological changes. Methods: Children and adolescents aged 10-16 y with heterozygous familial hypercholesterolaemia were administered fluvastatin (80 mg/d) for 2 y in a single-arm two-centre study. Carotid B-mode intima-media thickness (IMT) and M-mode arterial wall stiffness (β) were recorded. Eighty of the 85 enrolled subjects completed the trial. Results: The median decrease in low-density lipoprotein (LDL) cholesterol from baseline at last study visit was 33.9%; median decreases in total cholesterol, triglycerides and apolipoprotein B were 27.1%, 5.3% and 24.2%, respectively; the median increase in high-density lipoprotein (HDL) cholesterol was 5.3%. Changes in carotid arterial wall thickness and stiffness versus baseline were fractional and statistically non-significant (Δ IMT -0.005 mm, 95% CI -0.018 to +0.007 mm, n = 83; and Δ β = 0.017, 95% CI -0.219 to +0.253, n = 79). Adverse events, all non-serious, were reported by 58 subjects (68.2%); four were suspected to be drug-related. Change in hormone levels and sexual maturation were appropriate for this age group. Conclusion: Fluvastatin lowered LDL cholesterol, total cholesterol and apolipoprotein B levels effectively over a prolonged period in children and adolescents with heterozygous familial hypercholesterolaemia. Carotid IMT and wall stiffness remained largely unchanged. © 2006 Taylor & Francis.
Authors & Co-Authors
van der Graaf, Anouk
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Nierman, Melchior C.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Firth, Jean Catherine
South Africa, Cape Town
Faculty of Health Sciences
Wolmarans, Karen H.
South Africa, Cape Town
Faculty of Health Sciences
Marais, Adrian David
South Africa, Cape Town
Faculty of Health Sciences
de Groot, Eric E.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Statistics
Citations: 46
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1080/08035250600702602
ISSN:
08035253
e-ISSN:
16512227
Research Areas
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health