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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effectiveness of a new carrier-bound fibrin sealant versus argon beamer as haemostatic agent during liver resection: A randomised prospective trial
Langenbeck's Archives of Surgery, Volume 390, No. 2, Year 2005
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Description
Background and aims: A new carrier-bound fibrin sealant, TachoSil, is expected to be efficacious and safe as a haemostatic treatment in hepatic resection. Design: A prospective, randomised, open and controlled multicentre trial with intraoperative as well as postoperative assessment of efficacy and a 1 month follow-up period. Setting: Tertiary care centres. Patients/methods: One hundred and twenty-one patients requiring secondary haemostasis during planned liver resection. Patients with coagulation disorders and patients with persistent major bleeding after primary haemostatic measures were excluded. Intervention: Application of either carrier-bound fibrin sealant (n=59) or argon beamer (argon beam coagulator) (n=62) as secondary haemostatic treatment. Main outcome measure: Time to intraoperative haemostasis. Results: There was a significant superiority of TachoSil over argon beamer with regard to time to haemostasis (3.9 min, median 3.0, range 3-20 min vs 6.3 min, median 4.0, range 3-39 min) (P=0.0007). Haemoglobin concentration of drainage fluid was significantly lower on day 2 after surgery in TachoSil patients (1.1 mmol/l) than in argon beamer patients (2.3 mmol/l) (P=0.012). Overall, the frequency and causality of adverse events did not differ between the two treatment groups. Conclusion: TachoSil is superior to argon beamer in obtaining effective and fast intraoperative haemostasis. The safety data show TachoSil to be tolerable and safe for haemostatic treatment in liver resection. © Springer-Verlag 2005.
Authors & Co-Authors
Frilling, Andrea
Germany, Essen
Universitätsklinikum Essen
Stavrou, Gregor A.
Germany, Essen
Universitätsklinikum Essen
Mischinger, Hans Jörg
Austria, Graz
Lkh-universitätsklinikum Graz
De Hemptinne, Bernard
Belgium, Ghent
Universiteit Gent
Rokkjaer, Mogens
Denmark, Aarhus
Aarhus Universitetshospital
Klempnauer, Jürgen
Germany, Hannover
Hannover Medical School
Thörne, Anders
Sweden, Stockholm
Karolinska Universitetssjukhuset
Gloor, Beat
Switzerland, Bern
University Hospital Bern
Beckebaum, Susanne
Germany, Essen
Universitätsklinikum Essen
Ghaffar, Mohamed F.A.
Germany, Essen
Universitätsklinikum Essen
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Broelsch, Christopher Erich
Germany, Essen
Universitätsklinikum Essen
Statistics
Citations: 189
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1007/s00423-005-0543-x
ISSN:
14352443
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cohort Study