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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
IgA anti-actin antibodies in celiac disease
Gastroenterologie Clinique et Biologique, Volume 34, No. 8-9, Year 2010
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Description
Aims: The purpose of this study was to determine the sensitivity and specificity of IgA anti-actin antibodies (IgA-AAA) for celiac disease (CD), to investigate their usefulness as a marker of compliance in CD patients to the gluten-free diet (GFD), and to assess the relationship between their presence in the sera of CD patients and severity of intestinal mucosal damage. Patients and methods: A total of 182 patients with CD were studied: 63 patients were untreated; 50 patients were following a strict GFD; and 69 patients were non-compliant with a GFD. IgA-AAA was detected using a homemade enzyme-linked immunosorbent assay (ELISA). Results: IgA-AAA showed a sensitivity of 41.3% and a specificity of 71.4% for a diagnosis of CD. In children, the frequency of IgA-AAA detection was lower in those following a strict GFD (23.1%) compared with untreated patients (39.4%) and those not complying with a GFD (32.5%). In patients following a strict GFD, IgA-AAA detection was significantly less frequent in children than in adults (23.1% vs. 58.3%, respectively; P< 0.001). IgA-AAA was found in 17 out of 52 CD patients with total villous atrophy (32.7%), and in one out of 11 patients with subtotal villous atrophy (9%). Conclusion: IgA-AAA cannot replace anti-endomysium and anti-tissue transglutaminase antibodies in the diagnosis algorithm of CD, but it can serve as a reliable marker of severe intestinal mucosal damage in CD patients. © 2010 Elsevier Masson SAS.
Authors & Co-Authors
Achour, Achouak
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Thabet, Yosra
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Sakly, Wahiba
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Mankaï, Amani
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Sakly, Nabil
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Ayadi, Abdelkarim
Tunisia, Mahdia
Hôpital Tahar Sfar
Sfar, Mohammed Tahar
Tunisia, Mahdia
Hôpital Tahar Sfar
Amri, Fethi
Tunisia, Kairouan
Centre Hospitalo-universitaire Ibn el Jazzar de Kairouan
Harbi, Abdelaziz
Tunisia, Sousse
Chu Sahloul
Essoussi, Ahmed Sahloul
Tunisia, Sousse
Hopital Farhat Hached Sousse
Krifa, A.
Tunisia, Sousse
Hopital Farhat Hached Sousse
Ajmi, Salem Trimeche
Tunisia, Sousse
Chu Sahloul
Ghédira, Ibtissem
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Tunisia, Sousse
Hopital Farhat Hached Sousse
Statistics
Citations: 13
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1016/j.gcb.2010.01.023
Research Areas
Maternal And Child Health