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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in Northwest Ethiopia: New phylogenetic lineages found in Northwest Ethiopia
BMC Infectious Diseases, Volume 13, No. 1, Article 131, Year 2013
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Description
Background: Although Ethiopia ranks seventh among the world's 22 high-burden tuberculosis (TB) countries, little is known about strain diversity and transmission. In this study, we present the first in-depth analysis of the population structure and transmission dynamics of Mycobacterium tuberculosis strains from Northwest Ethiopia.Methods: In the present study, 244 M. tuberculosis isolates where analysed by mycobacterial interspersed repetitive unit - variable number tandem repeat 24-loci typing and spoligotyping methods to determine phylogenetic lineages and perform cluster analysis. Clusters of strains with identical genotyping patterns were considered as an indicator for the recent transmission.Results: Of 244 isolates, 59.0% were classified into nine previously described lineages: Dehli/CAS (38.9%), Haarlem (8.6%), Ural (3.3%), LAM (3.3%), TUR (2.0%), X-type (1.2%), S-type (0.8%), Beijing (0.4%) and Uganda II (0.4%). Interestingly, 31.6% of the strains were grouped into four new lineages and were named as Ethiopia_3 (13.1%), Ethiopia_1 (7.8%), Ethiopia_H37Rv like (7.0%) and Ethiopia_2 (3.7%) lineages. The remaining 9.4% of the isolates could not be assigned to the known or new lineages. Overall, 45.1% of the isolates were grouped in clusters, indicating a high rate of recent transmission.Conclusions: This study confirms a highly diverse M. tuberculosis population structure, the presence of new phylogenetic lineages and a predominance of the Dehli/CAS lineage in Northwest Ethiopia. The high rate of recent transmission indicates defects of the TB control program in Northwest Ethiopia. This emphasizes the importance of strengthening laboratory diagnosis of TB, intensified case finding and treatment of TB patients to interrupt the chain of transmission. © 2013 Tessema et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3605317/bin/1471-2334-13-131-S1.doc
Authors & Co-Authors
Tessema, Belay
Ethiopia, Gondar
University of Gondar
Germany, Leipzig
Universitätsklinikum Leipzig Und Medizinische Fakultät
Germany, Leipzig
Universität Leipzig
Beer, Joerg
Germany, Leipzig
Universitätsklinikum Leipzig Und Medizinische Fakultät
Merker, Matthias
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Emmrich, Frank
Germany, Leipzig
Universitätsklinikum Leipzig Und Medizinische Fakultät
Germany, Leipzig
Universität Leipzig
Sack, Ulrich
Germany, Leipzig
Universitätsklinikum Leipzig Und Medizinische Fakultät
Germany, Leipzig
Universität Leipzig
Rodloff, Arne Christian
Germany, Leipzig
Universitätsklinikum Leipzig Und Medizinische Fakultät
Niemann, Stefan
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Statistics
Citations: 82
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1186/1471-2334-13-131
e-ISSN:
14712334
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Case Study
Study Approach
Qualitative
Study Locations
Ethiopia
Uganda