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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Two distinct epidemics: The rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural guinea-bissau
Journal of Acquired Immune Deficiency Syndromes, Volume 53, No. 5, Year 2010
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Description
OBJECTIVES: To assess changes in HIV incidence and prevalence in Caió, a rural area of Guinea-Bissau, between 1990 and 2007. DESIGN: Three cross-sectional community surveys. Methods: In 1990, 1997, and 2007, surveys were conducted among adults. The prevalence of HIV-1 and of HIV-2 was estimated for each survey, and incidence rates were calculated for the first (1990-1997) and second period (1997-2007). Results: The HIV-1 incidence was approximately 4.5/1000 person-years in the two periods, whereas the HIV-2 incidence decreased from 4.7 (95% confidence interval 3.6-6.2) in the first to 2.0 (95% confidence interval 1.4-3.0) per 1000 person-years in the second period (P < 0.001). HIV-1 prevalence rose from 0.5% in 1990 to 3.6% in 2007, and HIV-2 prevalence decreased from 8.3% in 1990 to 4.7% in 2007. HIV-1 prevalence was less than 2% in 15 to 24 year olds in all surveys and was highest (7.2%) in 2007 among 45 to 54 year olds. The HIV-2 prevalence was fivefold higher in older subjects (â‰1-45 yr) compared with those less than 45 years in both sexes in 2007. Conclusions: HIV-1 incidence is stable, and its prevalence is increasing, whereas HIV-2 incidence and prevalence are both declining. In contrast with what has been observed in other sub-Saharan countries, HIV-1 prevalence is lower in younger age groups than older age groups. © 2010 by Lippincott Williams & Wilkins.
Authors & Co-Authors
van Tienen, Carla
Gambia, Banjul
Medical Research Council Laboratories Gambia
van der Loeff, Maarten Franciscus Schim V.D.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Netherlands, Amsterdam
Municipal Health Service of Amsterdam
Zaman, Syed M.A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United Kingdom, London
Public Health England
Vincent, Tim
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sarge-Njie, Ramu
Gambia, Banjul
Medical Research Council Laboratories Gambia
Peterson, Ingrid
Gambia, Banjul
Medical Research Council Laboratories Gambia
Leligdowicz, Aleksandra
Gambia, Banjul
Medical Research Council Laboratories Gambia
United Kingdom, Oxford
John Radcliffe Hospital
Jaye, Assan
Gambia, Banjul
Medical Research Council Laboratories Gambia
Rowland-Jones, Sarah Louise
Gambia, Banjul
Medical Research Council Laboratories Gambia
United Kingdom, Oxford
John Radcliffe Hospital
Aaby, Peter
Ghana, Accra
Indepth Network
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 68
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1097/QAI.0b013e3181bf1a25
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Guinea
Guinea-Bissau