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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1-4 in Italy
Scientific Reports, Volume 8, No. 1, Article 8988, Year 2018
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Description
Natural resistance-associated substitutions (RASs) are reported with highly variable prevalence across different HCV genotypes (GTs). Frequency of natural RASs in a large Italian real-life cohort of patients infected with the 4 main HCV-GTs was investigated. NS3, NS5A and NS5B sequences were analysed in 1445 HCV-infected DAA-naïve patients. Sanger-sequencing was performed by home-made protocols on 464 GT1a, 585 GT1b, 92 GT2c, 199 GT3a, 16 GT4a and 99 GT4d samples. Overall, 20.7% (301/1455) of patients showed natural RASs, and the prevalence of multiclass-resistance was 7.3% (29/372 patients analysed). NS3-RASs were particularly common in GT1a and GT1b (45.2-10.8%, respectively), mainly due to 80K presence in GT1a (17%). Almost all GTs showed high prevalence of NS5A-RASs (range: 10.2-45.4%), and especially of 93H (5.1%). NS5A-RASs with fold-change >100x were detected in 6.8% GT1a (30H/R-31M-93C/H), 10.3% GT1b (31V-93H), 28.4% GT2c (28C-31M-93H), 8.5% GT3a (30K-93H), 45.5% GT4a (28M-30R-93H) and 3.8% GT4d (28V-30S-93H). Sofosbuvir RAS 282T was never detected, while the 159F and 316N RASs were found in GT1b (13.4-19.1%, respectively). Natural RASs are common in Italian patients infected with HCV-GTs 1-4. High prevalence of clinically-relevant RASs (such as Y93H) supports the appropriateness of HCV resistance-test to properly guide DAA-based therapy. © 2018 The Author(s).
Authors & Co-Authors
Bertoli, A.
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Aragri, Marianna
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Lenci, Ilaria
Italy, Rome
Policlinico Tor Vergata
Teti, Elisabetta
Italy, Rome
Policlinico Tor Vergata
Polilli, Ennio
Italy, Pescara
Pescara General Hospital
Di Maio, Velia Chiara
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Gianserra, Laura
Italy, Rome
Sapienza Università Di Roma
Biliotti, Elisa
Italy, Rome
Sapienza Università Di Roma
Masetti, Chiara
Italy, Rome
Policlinico Tor Vergata
Magni, Carlo Federico
Italy, Milan
Asst Fatebenefratelli Sacco
Babudieri, Sergio
Italy, Sassari
Università Degli Studi Di Sassari
Nicolini, Laura Ambra
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Cacciatore, Pierluigi
Italy, Pescara
Pescara General Hospital
Sarmati, Loredana
Italy, Rome
Policlinico Tor Vergata
Pellicelli, A. M.
Italy, Rome
Azienda Ospedaliera San Camillo Forlanini
Paolucci, Stefania
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Craxì, Antonio
Italy, Palermo
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Morisco, Filomena
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Siciliano, Massimo
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Coppola, N.
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Iapadre, Nerio
Italy, L'aquila
Ospedale S. Salvatore
Puoti, Massimo
Italy, Milan
Asst Grande Ospedale Metropolitano Niguarda
Rizzardini, Giuliano
Italy, Milan
Asst Fatebenefratelli Sacco
Taliani, Gloria L.
Italy, Rome
Sapienza Università Di Roma
Pasquazzi, Caterina
Italy, Rome
Sapienza Università Di Roma
Andreoni, Massimo G.
Italy, Rome
Policlinico Tor Vergata
Parruti, Giustino
Italy, Pescara
Pescara General Hospital
Angelico, Mario
Italy, Rome
Policlinico Tor Vergata
Perno, Carlo Federico
Italy, Milan
Università Degli Studi Di Milano
Cento, Valeria
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Ceccherini-Silberstein, Francesca
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Andreone, Pietro
Italy, Bologna
Alma Mater Studiorum Università Di Bologna
Baldanti, F.
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Barbarini, Giorgio
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Boccaccio, Vincenzo
Italy, Rozzano
Humanitas Research Hospital
Bolis, Matteo
Italy, Milan
Asst Fatebenefratelli Sacco
Bonora, Stefano
Italy, Turin
Ospedale Amedeo Di Savoia
Borghi, Vanni
Unknown Affiliation
Brancaccio, Giuseppina
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Bruno, Savino R.
Italy, Rozzano
Humanitas Research Hospital
Bruzzone, Bianca Marisa
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Calvaruso, Vincenza
Italy, Palermo
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Caporaso, Nicola
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Colombatto, Piero
Italy, Pisa
Ospedale Santa Chiara Pisa
Cozzolongo, Raffaele
Italy, Rome
Scientific Irccs Network- Italian Ministry of Health
D'Ettorre, Gabriella
Italy, Rome
Sapienza Università Di Roma
De Luca, Andrea
Italy, Siena
Azienda Ospedaliera Universitaria Senese
Di Biagio, Antonio
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Di Perri, Giovanni
Italy, Turin
Ospedale Amedeo Di Savoia
Francioso, Simona
Italy, Rome
Policlinico Tor Vergata
Gaeta, Giovanni Battista
Italy, Naples
Università Degli Studi Della Campania Luigi Vanvitelli
Giorgini, Alessia M.
Italy, Milan
Università Degli Studi Di Milano
Grieco, Antonio
Italy, Rome
Università Cattolica Del Sacro Cuore, Campus Di Roma
Gubertini, Guido A.
Italy, Milan
Asst Fatebenefratelli Sacco
Landonio, Simona
Italy, Milan
Asst Fatebenefratelli Sacco
Lichtner, Miriam
Italy, Rome
Sapienza Università Di Roma
Marenco, Simona
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Maserati, Renato
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Melis, Michela
Italy, Sassari
Università Degli Studi Di Sassari
Menzaghi, Barbara
Italy, Varese
Azienda Ospedaliera Ospedale Di Circolo e Fondazione Macchi Di Varese
Micheli, Valeria
Italy, Milan
Asst Fatebenefratelli Sacco
Niero, Fosca P.
Italy, Milan
Asst Fatebenefratelli Sacco
Paoloni, Maurizio
Italy, Avezzano
Avezzano Hospital
Pieri, Alessandro
Italy, Pescara
Pescara General Hospital
Romagnoli, Dante
Italy, Modena
Università Degli Studi Di Modena e Reggio Emilia
Rossetti, Barbara
Italy, Siena
Azienda Ospedaliera Universitaria Senese
Sangiovanni, Vincenzo
Italy, Naples
Azienda Ospedaliera D. Cotugno
Sticchi, Laura
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Tarquini, Pierluigi L.
Italy, Teramo
G. Mazzini Hospital
Toniutto, Pierluigi
Italy, Udine
Università Degli Studi Di Udine
Vullo, Vincenzo
Italy, Rome
Sapienza Università Di Roma
Zazzi, Maurizio
Italy, Siena
Università Degli Studi Di Siena
Statistics
Citations: 38
Authors: 72
Affiliations: 32
Identifiers
Doi:
10.1038/s41598-018-26862-y
ISSN:
20452322
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study