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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
The effect of Dodonaea viscosa var. angustifolia on Candida albicans proteinase and phospholipase production and adherence to oral epithelial cells
Journal of Ethnopharmacology, Volume 124, No. 3, Year 2009
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Description
Aim of the study: This study investigated effect of a crude extract of Dodonaea viscosa on the proteinase and phospholipase production and adherence to epithelial cells by Candida albicans isolated from HIV positive and HIV negative patients. Materials and methods: Twenty Candida albicans strains isolated from HIV positive and 20 from HIV negative patients were investigated. The isolates were exposed to subinhibitory concentration of crude plant extract and adherence, proteinase and phospholipase production were assessed. The results were analysed using Student's t-test and a two-way ANOVA. Results: Dodonaea viscosa var. angustifolia inhibited the adherence of Candida albicans to oral epithelial cells (p = <0.01) but no significant effect of the plant extract on proteinase and phospholipase production was observed. Results from Candida albicans strains isolated from HIV positive and HIV negative patients were similar. Conclusions: Dodonaea viscosa var. angustifolia inhibited the adherence of Candida albicans to oral epithelial cells, which is the initial step of colonization in the infection process. This plant has a therapeutic potential at subinhibitory concentration. © 2009 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Patel, Mrudula
South Africa, Johannesburg
Faculty of Health Sciences
Gulube, Zandiswa
South Africa, Johannesburg
Faculty of Health Sciences
Dutton, Michael Francis
South Africa, Johannesburg
Faculty of Health Sciences
Statistics
Citations: 32
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.jep.2009.05.002
ISSN:
03788741
Research Areas
Health System And Policy
Infectious Diseases