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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Calcium channel blocking activity of Mentha longifolia L. explains its medicinal use in diarrhoea and gut spasm
Phytotherapy Research, Volume 24, No. 9, Year 2010
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Description
Mentha longifolia has a reputation in traditional medicine in the indications of diarrhoea and gut spasm. This study was carried out to provide a possible pharmacological basis for its medicinal use in hyperactive gut disorders. In a castor oil induced diarrhoeal model, the crude extract of Mentha longifolia (Ml.Cr), at doses of 100-1000 mg/kg, provided 31-80% protection, similar to loperamide. In isolated rabbit jejunum preparations, Ml.Cr caused inhibition of spontaneous and high K+-induced contractions, with respective EC50 values of 1.80 (1.34-2.24; n = 6-8) and 0.60 mg/mL (0.37-0.85; n = 6-8), which suggests spasmolytic activity, mediated possibly through calcium channel blockade (CCB). The CCB activity was further confirmed when pretreatment of the tissue with Ml.Cr (0.3-1 mg/mL) caused a rightward shift in the Ca++ concentration-response curves (CRCs), similar to verapamil. Loperamide also inhibited spontaneous and high K+-induced contractions and shifted the Ca++ CRCs to the right. Activity-directed fractionation revealed that the petroleum spirit fraction was more potent than the parent crude extract and aqueous fraction. These data indicate that the antidiarrhoeal and spasmolytic effects of the crude extract of Mentha longifolia are mediated through the presence of CCB-like constituent(s), concentrated in the petroleum spirit fraction and this study provides indirect evidence for its medicinal use in diarrhoea and spasm. Copyright © 2010 John Wiley & Sons, Ltd.
Authors & Co-Authors
Shah, Abdul Jabbar
Pakistan, Karachi
The Aga Khan University Medical College
Pakistan, Abbottabad
Comsats University Islamabad, Abbottabad Campus
Bhulani, Nizar Noorali
Pakistan, Karachi
The Aga Khan University Medical College
Khan, Sara Haroon
Pakistan, Karachi
The Aga Khan University Medical College
Rehman, Najeeb Ur
Pakistan, Karachi
The Aga Khan University Medical College
Gilani, Anwar ul Hassan
Pakistan, Karachi
The Aga Khan University Medical College
Saudi Arabia, Riyadh
King Saud University
Statistics
Citations: 52
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1002/ptr.3263
ISSN:
0951418X
e-ISSN:
10991573
Research Areas
Health System And Policy
Infectious Diseases