Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasma homocysteine in schizophrenia: Determinants and clinical correlations in Tunisian patients free from antipsychotics
Psychiatry Research, Volume 179, No. 1, Year 2010
Notification
URL copied to clipboard!
Description
The existence of association between hyperhomocysteinaemia (HHC) and schizophrenia has been suggested by several recent studies. This study aimed to determine the prevalence of HHC and its main determinants, and sought a correlation with clinical features in Tunisian patients with schizophrenia. Plasma homocysteine (Hcy), folate, and vitamin B12, as well as the C677T methylene tetrahydrofolate reductase (MTHFR) polymorphism, were studied in 33 patients with schizophrenia, all free from antipsychotic treatment, and 35 age- and smoking-habit-matched healthy subjects as controls. Biochemical determinations and psychometric evaluations were carried out in patients before the administration of antipsychotics. The prevalence of HHC was higher and plasma B12 vitamin was significantly lower in patients. There was no significant difference in genotypic distribution and allelic frequency of the C677T MTHFR polymorphism between groups. Hcy was significantly correlated to the 'anhedonia-asociality' subscales of the Scale for the Assessment of Negative Symptoms (SANS). This study showed an association between HHC and schizophrenia, especially with the negative symptoms of the disease. In the Tunisian population, HHC in schizophrenia seems to be linked to vitamin B12 deficiency, likely caused by a lack of dietary animal proteins. © 2010 Elsevier Ireland Ltd.
Authors & Co-Authors
Bouaziz, Noomen
Tunisia, Manouba
Université de Tunis el Manar, Hôpital Razi
Ayedi, Imen
Tunisia, Tunis
Hôpital la Rabta
Sidhom, Oussama
Tunisia, Manouba
Université de Tunis el Manar, Hôpital Razi
Kallel, Amani
Tunisia, Tunis
Hôpital la Rabta
Rafrafi, Rym
Tunisia, Manouba
Université de Tunis el Manar, Hôpital Razi
Jomaa, Riadh
Tunisia, Tunis
Hôpital la Rabta
Melki, Wahid
Tunisia, Manouba
Université de Tunis el Manar, Hôpital Razi
Feki, Moncef
Tunisia, Tunis
Hôpital la Rabta
Kaabechi, Naziha
Tunisia, Tunis
Hôpital la Rabta
El-Hechmi, Zouhaier
Tunisia, Manouba
Université de Tunis el Manar, Hôpital Razi
Statistics
Citations: 43
Authors: 10
Affiliations: 2
Identifiers
Doi:
10.1016/j.psychres.2010.04.008
ISSN:
01651781
Research Areas
Mental Health
Study Design
Cross Sectional Study