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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Consensus Report on Shigella Controlled Human Infection Model: Conduct of Studies
Clinical Infectious Diseases, Volume 69, Year 2019
Notification
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Description
Shigella causes morbidity and mortality worldwide, primarily affecting young children living in low-resource settings. It is also of great concern due to increasing antibiotic resistance, and is a priority organism for the World Health Organization. A Shigella vaccine would decrease the morbidity and mortality associated with shigellosis, improve child health, and decrease the need for antibiotics. Controlled human infection models (CHIMs) are useful tools in vaccine evaluation for early up- or down-selection of vaccine candidates and potentially useful in support of licensure. Over time, the methods employed in these models have become more uniform across sites performing CHIM trials, although some differences in conduct persist. In November 2017, a Shigella CHIM workshop was convened in Washington, District of Columbia. Investigators met to discuss multiple aspects of these studies, including study procedures, clinical and immunological endpoints, and shared experiences. This article serves as a uniform procedure by which to conduct Shigella CHIM studies. © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
Authors & Co-Authors
Talaat, Kawsar R.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Bourgeois, August Louis
United States, Washington, D.c.
Path
Frenck, Robert W.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Chen, Wilbur H.
United States, Baltimore
University of Maryland School of Medicine
MacLennan, Calman Alexander
Unknown Affiliation
Riddle, Mark S.
United States, Bethesda
Uniformed Services University of the Health Sciences
Suvarnapunya, Akamol Eddie
United States, Silver Spring
Walter Reed Army Institute of Research
Kotloff, Karen L.
United States, Baltimore
University of Maryland School of Medicine
Porter, Chad K.
United States, Silver Spring
Naval Medical Research Center
Statistics
Citations: 17
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1093/cid/ciz892
ISSN:
10584838
Research Areas
Maternal And Child Health