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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Asymptomatic celiac sprue in juvenile rheumatic diseases children
International Journal of Rheumatic Diseases, Volume 15, No. 2, Year 2012
Notification
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Description
Background: Celiac disease (CD) is the most frequent enteropathy in adults and its coexistence with other autoimmune diseases is frequent. Objective: To detect asymptomatic CD in children with rheumatic diseases by measuring tissue transglutaminase (tTG) antibodies and finding any relation to disease activity. Patients and methods: Setting and study design: The study included 60 children with juvenile rheumatic diseases consecutively from those attending the Rheumatology Clinics of Cairo University Hospitals: 30 juvenile rheumatoid arthritis (JRA), 10 juvenile systemic lupus erythematosus (SLE), 12 juvenile seronegative spondyloarthropathy and eight juvenile systemic sclerosis/polymyositis (SSc/PM) overlap syndrome were recruited during 2010. There were 22 male and 38 female patients. Thirty matched healthy controls were included. All children were subjected to thorough history taking, clinical examination and laboratory investigations. The body mass index (BMI) for age was used. All subjects had no gastrointestinal tract symptoms suggestive of CD and the tTG antibodies (IgA and IgG) were assessed. Results: The mean age of patients was 12.03±3.3years and disease duration 4.18±3.24years. The demographic, clinical and laboratory features of the children were studied and compared. The tTG was positive in 32 (53.3%) patients compared to 20% of the controls (P=0.03), being higher in females. In tTG-positive patients, the BMI was significantly lower, while white blood cell count, erythrocyte sedimentation rate and disease activity were significantly higher. Conclusions: tTG antibodies may be used as a screening test to identify asymptomatic CD associated with juvenile rheumatic diseases, especially those with active JRA or marked reduction in BMI. © 2011 The Authors. International Journal of Rheumatic Diseases © 2011 Asia Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty Ltd.
Authors & Co-Authors
A Gheita, Tamer
Egypt, Cairo
Faculty of Medicine
Fawzy, Samar Mohamed
Egypt, Cairo
Faculty of Medicine
El Baky, Abeer M.Nour El Din Abd
Egypt, Giza
National Research Centre
Gomaa, Howayda E.
Egypt, Giza
National Research Centre
Statistics
Citations: 17
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1111/j.1756-185X.2011.01681.x
ISSN:
17561841
e-ISSN:
1756185X
Research Areas
Maternal And Child Health
Participants Gender
Male
Female