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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Link between interleukin-10 level and outcome after ischemic stroke
NeuroImmunoModulation, Volume 17, No. 4, Year 2010
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Description
Objectives: The prognostic value of interleukin (IL)-10 in patients after acute ischemic stroke (IS) is not well understood. This study tested the hypothesis that serum levels of IL-10 are substantially increased after IS and predictive of IS outcome. Methods: Serum IL-10 levels were examined 48 h after acute IS in 135 consecutive patients, and in 20 healthy and 30 at-risk controls. Results: Mean serum IL-10 was significantly higher in IS patients than in both control groups (p < 0.0001, respectively). Additionally, serum IL-10 was significantly higher in patients with severe neurological impairment [defined as a score ≥12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe neurological impairment (NIHSS score <12) 48 h after IS (p < 0.0001). Furthermore, higher serum IL-10 was strongly and independently correlated with severe neurological impairment (NIHSS ≥12) 48 h after acute IS (p < 0.0001), and independently predictive of combined major adverse clinical outcomes (defined as recurrent IS, any cause of death or NIHSS ≥12) on day 90 following IS (p < 0.0001). Conclusions: Serum IL-10 is an independent prognosticator of IS outcome. Copyright © 2010 S. Karger AG.
Authors & Co-Authors
Chang, Li Teh
Taiwan, Pingtung
Meiho University
Yuen, Chunman
China, Hong Kong
Division of Neurosurgery
Liou, Chia Wei
Unknown Affiliation
Lu, Chenghsien
Unknown Affiliation
Chang, Wenneng
Unknown Affiliation
Youssef, Ali Ahmed
Egypt, Ismailia
Suez Canal University Hospitals
Yip, Hon Kan
Taiwan, Taipei
Chang Gung Memorial Hospital
Statistics
Citations: 37
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1159/000290038
ISSN:
10217401
Research Areas
Noncommunicable Diseases