Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Methadone induction in primary care for opioid dependence: A pragmatic randomized trial (ANRS Methaville)
PLoS ONE, Volume 9, No. 11, Article e112328, Year 2014
Notification
URL copied to clipboard!
Description
Objective: Methadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction models: primary care (PC) and SC. Copyright:; Methods: In this study, registered at ClinicalTrials.Gov (NCT00657397), opioid-dependent individuals not on methadone treatment for at least one month or receiving buprenorphine but needing to switch were randomly assigned to start methadone in PC (N = 155) or in SC (N = 66) in 10 sites in France. Visits were scheduled at months M0, M3, M6 and M12. The primary outcome was self-reported abstinence from street-opioids at 12 months (M12) (with an underlying 15% noninferiority hypothesis for PC). Secondary outcomes were abstinence during follow-up, engagement in treatment (i.e. completing the induction period), retention and satisfaction with the explanations provided by the physician. Primary analysis used intention to treat (ITT). Mixed models and the log-rank test were used to assess the arm effect (PC vs. SC) on the course of abstinence and retention, respectively.; Results: In the ITT analysis (n = 155 in PC, 66 in SC), which compared the proportions of street-opioid abstinent participants, 85/155 (55%) and 22/66 (33%) of the participants were classified as street-opioid abstinent at M12 in PC and SC, respectively. This ITT analysis showed the non-inferiority of PC (21.5 [7.7; 35.3]). Engagement in treatment and satisfaction with the explanations provided by the physician were significantly higher in PC than SC. Retention in methadone and abstinence during follow-up were comparable in both arms (p = 0.47, p = 0.39, respectively).; Conclusions: Under appropriate conditions, methadone induction in primary care is feasible and acceptable to both physicians and patients. It is as effective as induction in specialized care in reducing street-opioid use and ensuring engagement and retention in treatment for opioid dependence. © 2014 Carrieri et al.
Authors & Co-Authors
Carrieri, Patrizia
France, Paris
Inserm
France, Marseille
Sciences Economiques et Sociales de la Santé et Traitement de L'information Médicale
France, Marseille
Observatoire Regional de la Sante Provence-alpes-cote D'azur
Lions, Caroline
France, Paris
Inserm
France, Marseille
Sciences Economiques et Sociales de la Santé et Traitement de L'information Médicale
France, Marseille
Observatoire Regional de la Sante Provence-alpes-cote D'azur
Cohen, Julien
France, Paris
Inserm
France, Marseille
Sciences Economiques et Sociales de la Santé et Traitement de L'information Médicale
France, Marseille
Observatoire Regional de la Sante Provence-alpes-cote D'azur
Vray, Muriel M.
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Mora, Marion
France, Paris
Inserm
France, Marseille
Sciences Economiques et Sociales de la Santé et Traitement de L'information Médicale
France, Marseille
Observatoire Regional de la Sante Provence-alpes-cote D'azur
Marcellin, Fabienne
France, Paris
Inserm
France, Marseille
Sciences Economiques et Sociales de la Santé et Traitement de L'information Médicale
France, Marseille
Observatoire Regional de la Sante Provence-alpes-cote D'azur
Spire, Bruno
France, Paris
Inserm
France, Marseille
Sciences Economiques et Sociales de la Santé et Traitement de L'information Médicale
France, Marseille
Observatoire Regional de la Sante Provence-alpes-cote D'azur
Roux, Perrine
France, Paris
Inserm
France, Marseille
Sciences Economiques et Sociales de la Santé et Traitement de L'information Médicale
France, Marseille
Observatoire Regional de la Sante Provence-alpes-cote D'azur
Statistics
Citations: 32
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0112328
ISSN:
19326203
Research Areas
Health System And Policy
Substance Abuse
Study Design
Cohort Study