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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate
International Journal of Pharmaceutics, Volume 285, No. 1-2, Year 2004
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Description
Purpose: To prepare a self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate, with enhanced dissolution and better chance of oral absorption. Method: All-trans-retinol acetate SNEDDS was prepared using different concentrations of soybean oil (solvent) Cremophor EL (surfactant) and Capmul MCM-C8 (co-surfactant). Particle size and turbidity of the SNEDDS were determined after adding water to the oily solution. Dissolution profile of SNEDDS filled in hydroxyl propyl methyl cellulose (HPMC) capsules was determined by using water in USP apparatus 2. Ternary phase diagrams were constructed to identify the self-nanoemulsified region. The SNEDDS were evaluated by the visual observation, turbidity in nephrometric turbidity units (NTU), mean particle size (μm) and Fourier transformed-infrared spectroscopy (FT-IR). SNEDDS were thermally characterized using differential scanning calorimetry (DSC) to ensure the compatibility of the SNEDDS ingredient. Results: From the data obtained in this work, it was clear that surfactant to co-surfactant ratio has the main impact on the physical characteristics of the emulsion formed. The optimum surfactant to co-surfactant ratio was found to be 2:1 (37.5-50% for Cremophor EL, and 18.75-25% for Capmul MCM-C8). With this ratio, the resultant nanoemulsions obtained have a particle size range of 0.103-0.051 μm, turbidity range of 18.12-2.18 NTU and t 30 values (cumulative% all-trans-retinol acetate dissolved in 30 min) of 90.42-99.5. Also the thermograms obtained from DSC experiments showed that there is no incompatibility or interaction between the SNEDDS ingredients (soybean oil, Cremophor EL, and Capmul MCM-C8) and all-trans-retinol acetate. Conclusion: The present study revealed that the self-nanoemulsified drug delivery system of all-trans-retinol acetate increased its dissolution rate and has the potential to enhance its bioavailability without interaction or incompatibility between the ingredients. © 2004 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Taha, Ehab Ibrahim
United States, Amarillo
Texas Tech University Health Sciences Center at Amarillo
Kuwait, Kuwait City
Kuwait University
Al-Saidan, S.
Kuwait, Kuwait City
Kuwait University
Samy, Ahmed Mahmoud
Egypt, Cairo
Faculty of Pharmacy
Khan, Mansoor A.
United States, Amarillo
Texas Tech University Health Sciences Center at Amarillo
United States, Silver Spring
Food and Drug Administration
Statistics
Citations: 123
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.ijpharm.2004.03.034
ISSN:
03785173
Research Areas
Environmental
Health System And Policy