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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Latent tuberculosis infection screening and treatment in congregate settings (TB FREE COREA): Protocol for a prospective observational study in Korea
BMJ Open, Volume 10, No. 2, Article e034098, Year 2020
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Description
Introduction South Korea regards tuberculosis (TB) incidence in congregate settings as a serious problem. To this end, systematic latent TB infection (LTBI) diagnosis and treatment were provided to approximately 1.2 million individuals in high-risk congregate settings. Methods and analysis We designed a prospective cohort study of individuals tested for LTBI, based on the data collected on all persons screened for LTBI as part of the 2017 congregate settings programme in South Korea. Four types of databases are kept: LTBI screening database (personal information and LTBI test results), national health information (NHI) database (socio-demographic data and comorbidities), public healthcare information system (PHIS) database, and the Korean national TB surveillance system database (TB outcomes). Information regarding LTBI treatment at private hospitals and public health centres is collected from NHI and PHIS databases, respectively. The screening data are cleaned, duplicates are removed, and, where appropriate, re-coded to analyse specific exposures and outcomes. The primary objective is to compare the number of active TB cases prevented within 2 years between participants undergoing treatment and not undergoing treatment in the LTBI screening programme in congregate settings. Cascade of care for LTBI diagnosis and treatment will be evaluated among those with a positive LTBI test result. A Cox proportional hazards model will be applied to determine the risk factors for developing active TB. Ethics and dissemination The protocol is approved by the institutional review boards of Incheon St. Mary's Hospital, the Catholic University of Korea. Study results will be disseminated through peer-reviewed journals and conference presentations. Trial registration number KCT0003905. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Authors & Co-Authors
Stagg, Helen Ruth
United Kingdom, Edinburgh
The University of Edinburgh
Lipman, Marc CI
United Kingdom, London
Royal Free London Nhs Foundation Trust
United Kingdom, London
University College London
Rangaka, Molebogeng Xheeda
United Kingdom, London
University College London
Park, Jae-seuk
South Korea, Cheonan
Dankook University, College of Medicine
Kim, Jusang
South Korea, Seoul
College of Medicine of the Catholic University of Korea
Statistics
Citations: 6
Authors: 5
Affiliations: 7
Identifiers
Doi:
10.1136/bmjopen-2019-034098
ISSN:
20446055
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative