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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells
Gastroenterology, Volume 97, No. 1, Year 1989
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Description
In this immunocytochemical study, we have analyzed the developmental profile and phenotypic expression of the endocrine cell antigens chromogranin, 5-hydroxytryptamine, gastrin/cholecystokinin, cholecystokinin (9-20), somatostatin, somatostatin 28 (1-14), somatostatin cryptic peptide, glucagon, glucagonlike peptides 1 and 2, glicentin, peptide YY, glucose-dependent insulinotropic peptide, secretin, neurotensin, and substance P in human fetal stomach and intestine. All currently identifiable endocrine cell types were detected by 10 wk of gestation. Immunostaining for the endocrine cell marker chromogranin revealed abundant endocrine cells in the earliest specimens (8 wk of gestation) with a relatively higher frequency in both proximal duodenum and distal colon/rectum compared with other areas. Quantification of endocrine cells showed an increase with age that was roughly parallel to the growth of the gut as a whole. These studies show that the diversity of the endocrine component of the gut appears to be established by 10 wk of gestation and that gut activity is preceded by the development of a fully differentiated endocrine component, which may subserve or even initiate the onset of functional maturity. © 1989.
Authors & Co-Authors
Facer, Paul
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
Bishop, Anne E.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
Cole, G. A.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
Aitchison, M.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
Kendall, Charles H.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
van Aswegen, G.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
Penketh, Richard J.A.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
Rodek, C. H.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
McKeever, P.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
Polak, Juliam Margaret P.
United Kingdom, London
Imperial College Faculty of Medicine
United Kingdom, Glasgow
Western Infirmary
United Kingdom, Leicester
Leicester Royal Infirmary
South Africa, Potchefstroom
North-west University
United Kingdom, Harrow
Northwick Park Hospital
United Kingdom, London
Queen Charlotte's and Chelsea Hospital
Statistics
Citations: 46
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/0016-5085(89)91414-5
ISSN:
00165085