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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Toxoplasma gondii immunoglobulin G antibodies and nonfatal suicidal self-directed violence
Journal of Clinical Psychiatry, Volume 73, No. 8, Year 2012
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Description
Objective: The primary aim was to relate Toxoplasma gondii seropositivity and serointensity to scores on the self-rated Suicide Assessment Scale (SUAS-S). Another aim was to reevaluate the previously reported positive association between T gondii serointensity and a history of nonfatal suicidal self-directed violence. Method: This cross-sectional, observational study compared T gondii serointensity and seropositivity in plasma from 54 adult suicide attempters (inpatients at Lund University Hospital, Lund, Sweden) and 30 adult control subjects (randomly selected from the municipal population register in Lund, Sweden) recruited between 2006 and 2010. The potential of patients and controls for self-directed violence was evaluated with the SUAS-S. Psychiatric diagnoses were made according to DSM-IV criteria. Plasma samples were tested for immunoglobulin G antibodies to T gondii, cytomegalovirus, and herpes simplex virus type 1. Data were analyzed using multivariable logistic regression to investigate the association between T gondii serointensity or seropositivity and a history of nonfatal suicidal selfdirected violence; multivariable linear regression was used to explore the relationship between T gondii serointensity or seropositivity and the SUAS-S. Both regression models included sex, age, and body mass index as covariates. Results: Seropositivity of T gondii (adjusted odds ratio [OR] = 7.12; 95% CI, 1.66-30.6; P = .008) and serointensity of T gondii (adjusted OR = 2.01; 95% CI, 1.09-3.71; P = .03) were positively associated with a history of nonfatal suicidal self-directed violence. Seropositivity of T gondii was associated with higher SUAS-S scores, a relationship significant for the whole sample (P = .026), but not for suicide attempters only. No significant associations with other pathogens were identified. Conclusions: These results are consistent with previous reports on the association between T gondii infection and nonfatal suicidal self-directed violence. Confirming these results in future large longitudinal studies and including suicide as an outcome may lead to novel individualized approaches in suicide prevention. © Copyright 2012 Physicians Postgraduate Press, Inc.
Authors & Co-Authors
Zhang, Yuanfen
United States, Baltimore
University of Maryland School of Medicine
United States, Washington, D.c.
Dc Department of Mental Health
Träskman-Bendz, Lil
Sweden, Lund
Lunds Universitet
Janelidze, Shorena
Sweden, Lund
Lunds Universitet
Langenberg, Patricia W.
United States, Baltimore
University of Maryland School of Medicine
Saleh, Ahmed
United States, Baltimore
University of Maryland School of Medicine
Egypt, Giza
Faculty of Science
Constantine, Niel T.
United States, Baltimore
University of Maryland School of Medicine
Okusaga, Olaoluwa
United States, Baltimore
University of Maryland School of Medicine
United States, Washington, D.c.
Dc Department of Mental Health
Bay-Richter, Cecilie
Sweden, Lund
Lunds Universitet
Brundin, Lena
Sweden, Lund
Lunds Universitet
United States, East Lansing
Michigan State University
Postolache, Teodor T.
United States, Baltimore
University of Maryland School of Medicine
United States, Baltimore
Veterans Affairs Capitol Health Care Network Veterans Integrated Service Network 5
United States, Washington
National Center for the Treatment of Phobias
Statistics
Citations: 99
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.4088/JCP.11m07532
ISSN:
01606689
Research Areas
Health System And Policy
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study