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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Correlates of HIV Acquisition in a Cohort of Black Men Who Have Sex with Men in the United States: HIV Prevention Trials Network (HPTN) 061
PLoS ONE, Volume 8, No. 7, Article e70413, Year 2013
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Description
Background:Black men who have sex with men (MSM) in the United States (US) are affected by HIV at disproportionate rates compared to MSM of other race/ethnicities. Current HIV incidence estimates in this group are needed to appropriately target prevention efforts.Methods:From July 2009 to October 2010, Black MSM reporting unprotected anal intercourse with a man in the past six months were enrolled and followed for one year in six US cities for a feasibility study of a multi-component intervention to reduce HIV infection. HIV incidence based on HIV seroconversion was calculated as number of events/100 person-years. Multivariate proportional hazards modeling with time-dependent covariates was used to identify correlates of HIV acquisition.Results:Of 1,553 Black MSM enrolled, 1,164 were HIV-uninfected at baseline and included in follow-up. Overall annual HIV incidence was 3.0% (95% confidence interval (CI): 2.0, 4.4%) and 5.9% among men ≤30 years old (95% CI: 3.6, 9.1%). Men ≤30 years old reported significantly higher levels of sexual risk and were more likely to have a sexually transmitted infection diagnosed during follow-up. Younger men also were more likely to not have a usual place for health care, not have visited a health care provider recently, and to have unmet health care needs. In multivariate analysis, age ≤30 years (hazard ratio (HR): 3.4; 95% CI: 1.4, 8.3) and unprotected receptive anal intercourse with HIV-positive or unknown status partners (HR: 4.1; 95% CI: 1.9, 9.1) were significantly associated with HIV acquisition.Conclusion:In the largest cohort of prospectively-followed Black MSM in the US, HIV incidence was high, particularly among young men. Targeted, tailored and culturally appropriate HIV prevention strategies incorporating behavioral, social and biomedical based interventions are urgently needed to lower these rates. © 2013 Koblin et al.
Authors & Co-Authors
Koblin, Beryl A.
United States, New York
New York Blood Center
Mayer, Kenneth H.
United States, Boston
Fenway Community Health Center
Eshleman, Susan H.
United States, Baltimore
Johns Hopkins School of Medicine
Wang, Lei
United States, Seattle
Fred Hutchinson Cancer Center
Mannheimer, Sharon B.
United States, New York
Mailman School of Public Health
Shoptaw, Steven J.
United States, Los Angeles
University of California, Los Angeles
Magnus, Manya
United States, Washington, D.c.
Milken Institute School of Public Health
Buchbinder, Susan P.
United States, San Francisco
San Francisco Department of Public Health
Wilton, Leo
United States, Binghamton
Binghamton University State University of new York
Liu, Tingyuan
United States, Seattle
Fred Hutchinson Cancer Center
Cummings, Vanessa
United States, Baltimore
Johns Hopkins School of Medicine
Piwowar-Manning, Estelle M.
United States, Baltimore
Johns Hopkins School of Medicine
Fields, Sheldon D.
United States, Miami
Florida International University
Griffith, Sam B.
United States, Durham
Fhi 360
Elharrar, Vanessa N.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Wheeler, Darrell P.
United States, Chicago
Loyola University Chicago
Statistics
Citations: 186
Authors: 16
Affiliations: 14
Identifiers
Doi:
10.1371/journal.pone.0070413
ISSN:
19326203
Research Areas
Environmental
Infectious Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Male