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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Hypertension, diuretics and antihypertensives in relation to bladder cancer
Carcinogenesis, Volume 31, No. 11, Year 2010
Notification
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Description
The aim of this study is to investigate the relationships between hypertension, hypertension medication and bladder cancer risk in a population-based case-control study conducted in Los Angeles. Non-Asians between the ages of 25 and 64 years with histologically confirmed bladder cancers diagnosed between 1987 and 1996 were identified through the Los Angeles County Cancer Surveillance Program. A total of 1585 cases and their age-, gender- and race-matched neighborhood controls were included in the analyses. Conditional logistic regression models were used to examine the relationship between history of hypertension, medication use and bladder cancer risk. A history of hypertension was not related to bladder cancer; however, among hypertensive individuals, there was a significant difference in bladder cancer risk related to the use of diuretics or antihypertensive drugs (P for heterogeneity = 0.004). Compared with individuals without hypertension, hypertensive individuals who regularly used diuretics/antihypertensives had a similar risk [odds ratio (OR) 1.06; 95% confidence interval (CI) 0.86-1.30], whereas untreated hypertensive subjects had a 35% reduction in risk (OR: 0.65; 95% CI: 0.48-0.88). A greater reduction in bladder cancer risk was observed among current-smokers (OR: 0.43; 95% CI: 0.27-0.71) and carriers of GSTM1-null (homozygous absence) genotypes (OR: 0.43; 95% CI: 0.22-0.85). Similarly, among smokers with GSTM1-null genotype, levels of 4-aminobiphenyl-hemoglobin adducts were significantly lower among untreated hypertensive individuals (45.7 pg/g Hb) compared with individuals without hypertension (79.8 pg/g Hb) (P = 0.009). In conclusion, untreated hypertension was associated with a reduced risk of bladder cancer. © The Author 2010. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Esteban Castelao, J.
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Spain, Vigo
Complejo Hospitalario Universitario de Vigo
Yuan, Jianmin
United States, Minneapolis
University of Minnesota Twin Cities
Stern, Mariana Carla
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Conti, David V.
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Cortessis, Victoria K.
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Coetzee, Gerhard A.
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Pike, Malcolm C.
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Gago-Dominguez, Manuela
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Statistics
Citations: 29
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1093/carcin/bgq173
ISSN:
14602180
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study