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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis
Journal of Immunology, Volume 182, No. 2, Year 2009
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Description
Galectin-3 (Gal-3) is a member of the β-galactoside-binding lectin family and plays an important role in inflammation. However, the precise role of Gal-3 in autoimmune diseases remains obscure. We have investigated the functional role of Gal-3 in experimental autoimmune encephalomyelitis (EAE) following immunization with myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide. Gal-3 deficient (Gal-3-/-) mice developed significantly milder EAE and markedly reduced leukocyte infiltration in the CNS compared with similarly treated wild-type (WT) mice. Gal-3-/- mice also contained fewer monocytes and macrophages but more apoptotic cells in the CNS than did WT mice. Following Ag stimulation in vitro, lymph node cells from the immunized Gal-3-/- mice produced less IL-17 and IFN-γ than did those of the WT mice. In contrast, Gal-3-/- mice produced more serum IL-10, IL-5, and IL-13 and contained higher frequency of Foxp3+ regulatory T cells in the CNS than did the WT mice. Furthermore, bone marrow-derived dendritic cells from Gal-3-/- mice produced more IL-10 in response to LPS or bacterial lipoprotein than did WT marrow-derived dendritic cells. Moreover, Gal-3-/- dendritic cells induced Ag-specific T cells to produce more IL-10, IL-5, and IL-12, but less IL-17, than did WT dendritic cells. Taken together, our data demonstrate that Gal-3 plays an important disease-exacerbating role in EAE through its multifunctional roles in preventing cell apoptosis and increasing IL-17 and IFN-γ synthesis, but decreasing IL-10 production. Copyright © 2009 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Jiang, Hui Rong
United Kingdom, Glasgow
University of Glasgow
Al Rabesi, Z.
United Arab Emirates, Al Ain
United Arab Emirates University
Mensah-Brown, Eric P.K.
United Arab Emirates, Al Ain
United Arab Emirates University
Shahin, Allen
United Arab Emirates, Al Ain
United Arab Emirates University
Xu, Damo
United Kingdom, Glasgow
University of Glasgow
Goodyear, Carl S.
United Kingdom, Glasgow
University of Glasgow
Fukada, Sandra Y.
United Kingdom, Glasgow
University of Glasgow
Liu, F. T.
United States, Davis
University of California, Davis
Liew, Foo Y.
United Kingdom, Glasgow
University of Glasgow
Lukic, Miodrag L.
United Arab Emirates, Al Ain
United Arab Emirates University
Serbia, Kragujevac
University of Kragujevac
Statistics
Citations: 186
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.4049/jimmunol.182.2.1167
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Cancer
Maternal And Child Health