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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis
Atherosclerosis, Volume 224, No. 2, Year 2012
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Description
Introduction: Rheumatoid arthritis (RA) is an inflammatory disease associated with increased cardiovascular (CV) mortality. A recent study has disclosed association between NFKB1-94ATTG ins/del polymorphism and higher risk of coronary heart disease in healthy Caucasians. Because of that, we assessed the influence of this polymorphism in the risk of CV disease in RA patients. Material and methods: 1437 Spanish patients with RA were genotyped for the NFKB1-94ATTG ins/del polymorphism. Two hundred and seventy-one of them (18.8%) had experienced CV events. Results: After adjusting for sex, age at RA diagnosis and traditional CV risk factors RA patients carrying the NFKB1 del/del genotype had higher risk of CV events than those with ins/ins genotype (Hazard ratio [HR] = 1.76, 95% CI: 1.05-2.97, p = 0.03), while heterozygous patients had an intermediate (but non-significant) risk (HR = 1.31, 95% CI: 0.90-1.92, p = 0.16). Conclusion: Our results suggest that NFKB1-94ATTG ins/del polymorphism is associated with CV disease in patients with RA. © 2012 Elsevier Ireland Ltd.
Authors & Co-Authors
López-Mejías, Raquel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Bermúdez, Mercedes G.
Spain, Madrid
Consejo Superior de Investigaciones Científicas
González-Juanatey, Carlos
Spain, Lugo
Complejo Hospitalario Xeral Calde
Castañeda, Santos
Spain, Madrid
Hospital Universitario de la Princesa
Miranda-Filloy, José Alberto
Spain, Lugo
Complejo Hospitalario Xeral Calde
Gómez-Vaquero, Carmen
Spain, Barcelona
Hospital Universitari de Bellvitge
Fernàndez-Gutiérrez, Benjamín
Spain, Madrid
Hospital Clínico San Carlos
Balsa, Alejando
Spain, Madrid
Hospital Universitario la Paz
Pascual-Salcedo, Dora
Spain, Madrid
Hospital Universitario la Paz
Blanco-Alonso, Ricardo
Spain, Santander
Hospital Universitario Marqués de Valdecilla
González-Álvaro, Isidoro
Spain, Madrid
Hospital Universitario de la Princesa
Llorca-Díaz, Javier Francisco
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Statistics
Citations: 81
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1016/j.atherosclerosis.2012.06.008
ISSN:
18791484
Research Areas
Environmental
Genetics And Genomics
Noncommunicable Diseases