Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism
Microbes and Infection, Volume 11, No. 8-9, Year 2009
Notification
URL copied to clipboard!
Description
Regulated upon activation, normal T-cell expressed, and secreted (RANTES, CCL-5) is an important immunoregulatory mediator that is suppressed in children with malarial anemia (MA). Although pro-inflammatory (e.g., TNF-α, IL-1β and IFN-γ) and anti-inflammatory (e.g., IL-4, IL-10 and IL-13) cytokines regulate RANTES production, their effect on RANTES in children with MA has not been determined. Since intraleukocytic malarial pigment, hemozoin (Hz), causes dysregulation in chemokine and cytokine production, the impact of naturally acquired Hz (pfHz) on RANTES and RANTES-regulatory cytokines (TNF-α, IFN-γ, IL-1β, IL-4, IL-10, and IL-13) was examined. Circulating RANTES levels progressively declined with increasing levels of pigment-containing monocytes (PCM) (P = 0.035). Additional experiments in cultured peripheral blood mononuclear cells (PBMC) showed that monocytic acquisition of pfHz (in vivo) was associated with suppression of RANTES under baseline (P = 0.001) and stimulated conditions (P = 0.072). Although high PCM levels were associated with decreased circulating IFN-γ (P = 0.003) and IL-10 (P = 0.010), multivariate modeling revealed that only PCM (P = 0.048, β = -0.171) and IL-10 (P < 0.0001, β = -0.476) were independently associated with RANTES production. Subsequent in vitro experiments revealed that blockade of endogenous IL-10 significantly increased RANTES production (P = 0.028) in PBMC from children with naturally acquired Hz. Results here demonstrate that monocytic acquisition of Hz suppresses RANTES production in children with MA through an IL-10-dependent mechanism. © 2009 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Were, Tom
United States, Albuquerque
The University of new Mexico
Kenya, Nairobi
Kenyatta University
Davenport, Gregory C.
United States, Albuquerque
Unm School of Medicine
Yamo, Emmanuel O.
United States, Albuquerque
The University of new Mexico
Hittner, James Bryant
United States, Charleston
College of Charleston
Awandare, Gordon Akanzuwine
United States, Albuquerque
The University of new Mexico
United States, Silver Spring
Walter Reed Army Institute of Research
Otieno, Michael F.
Kenya, Nairobi
Kenyatta University
Ouma, Collins
United States, Albuquerque
The University of new Mexico
Orago, Alloys S.S.
Kenya, Nairobi
National Aids Control Council
Vulule, John M.
Kenya, Nairobi
Kenya Medical Research Institute
Ong'Echa, John Michael O.
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
Unm School of Medicine
Perkins, Douglas Jay
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
Unm School of Medicine
Statistics
Citations: 33
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.micinf.2009.04.021
ISSN:
12864579
e-ISSN:
1769714X
Research Areas
Maternal And Child Health