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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association of Chlamydia trachomatis serology with tubal infertility in Nigerian women
Journal of Obstetrics and Gynaecology Research, Volume 33, No. 5, Year 2007
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Description
Aim: To determine the association between tubal infertility and Chlamydia trachomatis in Nigerian women. Methods: This case-control study is from the Departments of Obstetrics and Gynecology of two tertiary hospitals in Nigeria. One hundred and sixty-two infertile patients with tubal occlusion had 162 pregnant women matched for age as controls. Information on sociodemographic variables, sexual and reproductive risk factors, and history of previous pelvic infections were elicited using a study protocol. The prevalence of Chlamydia Trachomatis antibody was determined for cases and controls. Results: The prevalence of serum Chlamydia antibody was significantly higher in cases (65.8%) compared with controls (17.3%; P < 001). The effects of Chlamydia antibodies on infertility were strengthened in the multivariate model controlling for Chlamydia antibodies and gynecologic symptoms, compared to the univariate model. However, the association was attenuated and non-significant when the effects of gynecologic symptoms, sociodemographic characteristics, contraceptive and sexual history were controlled in the conditional logistic regression model. The strongest independent predictors of infertility in the model were vaginal discharge, education less than tertiary and more than three lifetime sexual partners (proxies of sexually transmitted infections). Conclusions: There was no strong independent association between Chlamydia antibodies and the risk of being infertile in Nigerian women. By contrast, the proxies of sexually transmitted infections were significant predictors of infertility in the women. Efforts to address these factors, which are proxies of sexually transmissible infections, Chlamydia infection, and health-seeking behavior for these infections, will likely contribute to reducing the burden of infertility in Nigerian women. © 2007 The Authors.
Authors & Co-Authors
Omo-Aghoja, Lawrence Osuakpor
Nigeria, Abraka
Delta State University Nigeria
Okonofua, Friday Ebhodaghe
Nigeria, Benin
University of Benin
Nigeria, Benin
Women's Health and Action Research Center
Sweden, Stockholm
Karolinska Institutet
Onemu, S. O.
Nigeria, Benin
University of Benin
Nigeria, Benin
Women's Health and Action Research Center
Larsen, Ulla Margrethe
United States, Boston
Harvard T.h. Chan School of Public Health
Bergström, Staffan E.
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 33
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1111/j.1447-0756.2007.00633.x
ISSN:
13418076
e-ISSN:
14470756
Research Areas
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Nigeria
Participants Gender
Female