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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antimicrobial activity of the methanolic extracts and compounds from Vismia laurentii De Wild (Guttiferae)
Journal of Ethnopharmacology, Volume 109, No. 3, Year 2007
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Description
Methanolic extracts prepared from the leaves, twigs and the roots of Vismia laurentii De Wild as well as nine compounds isolated from these crude extracts, were tested for their antimicrobial activity against Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and two Candida species using disc diffusion and well micro-dilution methods. The disc diffusion assay indicated that the crude extract was active against all the pathogens tested, whereas isolated compounds showed selective activities. The degree of sensitivity of the test organisms to purified compounds varied from 25 to 90%. Fridelin (8) was found to be the most active compound, while Bivismiaquinone (3) was the least active. The lowest minimum inhibition concentration (MIC) values as obtained by the micro-dilution assays were 19.53 and 1.22 μg/ml for the crude extracts and purified compounds, respectively. The lowest value for the purified compounds (1.22 μg/ml) was obtained with O1-demethyl-3′,4′-deoxypsorospermin-3′,4′-diol (6) on Candida gabrata and Bacillus subtilis; 1,8-dihydroxy-6-methoxy-3-methylanthraquinone (5) on Bacillus subtilis and 6-deoxyisojacareubin (7) on Bacillus stearothermophilus. These results provide promising baseline information for the potential use of these crude extracts as well as some of the isolated compounds in the treatment of bacterial and fungal infections. © 2006 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Kuete, Victor
Cameroon, Yaounde
Université de Yaoundé I
Nguemeving, Jean Robert
Cameroon, Yaounde
Université de Yaoundé I
Penlap-Beng, Véronique Penlap
Cameroon, Yaounde
Université de Yaoundé I
Azébazé, Anatole Guy Blaise
Cameroon, Douala
University of Douala
Etoa, François Xavier
Cameroon, Yaounde
Université de Yaoundé I
Meyer, Michèle
France, Paris
Museum National D'histoire Naturelle
Bodo, Bernard
France, Paris
Museum National D'histoire Naturelle
Nkengfack, Augustin Ephrem
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 103
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.jep.2006.07.044
ISSN:
03788741