Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Use of labour induction and risk of cesarean delivery: A systematic review and meta-analysis
CMAJ. Canadian Medical Association Journal, Volume 186, No. 9, Year 2014
Notification
URL copied to clipboard!
Description
Background: Induction of labour is common, and cesarean delivery is regarded as its major complication. We conducted a systematic review and meta-analysis to investigate whether the risk of cesarean delivery is higher or lower following labour induction compared with expectant management. Methods: We searched 6 electronic databases for relevant articles published through April 2012 to identify randomized controlled trials (RCTs) in which labour induction was compared with placebo or expectant management among women with a viable singleton pregnancy. We assessed risk of bias and obtained data on rates of cesarean delivery. We used regression analysis techniques to explore the effect of patient characteristics, induction methods and study quality on risk of cesarean delivery. Results: We identified 157 eligible RCTs (n = 31 085). Overall, the risk of cesarean delivery was 12% lower with labour induction than with expectant management (pooled relative risk [RR] 0.88, 95% confidence interval [CI] 0.84-0.93; I2 = 0%). The effect was significant in term and post-term gestations but not in preterm gestations. Meta-regression analysis showed that initial cervical score, indication for induction and method of induction did not alter the main result. There was a reduced risk of fetal death (RR 0.50, 95% CI 0.25-0.99; I2 = 0%) and admission to a neonatal intensive care unit (RR 0.86, 95% CI 0.79-0.94), and no impact on maternal death (RR 1.00, 95% CI 0.10-9.57; I2 = 0%) with labour induction. Interpretation: The risk of cesarean delivery was lower among women whose labour was induced than among those managed expectantly in term and post-term gestations. There were benefits for the fetus and no increased risk of maternal death. © 2014 Canadian Medical Association or its licensors.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4049989/bin/supp_186_9_665__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4049989/bin/supp_130925_labour-khan-appendix_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4049989/bin/supp_130925_labour-khan-appendix_2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4049989/bin/supp_130925_labour-khan-appendix_3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4049989/bin/supp_130925_labour-khan-appendix_4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4049989/bin/supp_130925_labour-khan-appendix_5.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4049989/bin/supp_130925_labour-khan-appendix_6.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4049989/bin/supp_130925_labour-khan-appendix_7.pdf
Authors & Co-Authors
Mishanina, Ekaterina
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Rogozinska, Ewelina
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Thatthi, Tej
Kenya, Nairobi
University of Nairobi Medical School
Uddin-Khan, Rehan
United Kingdom, London
Barts Health Nhs Trust
Khan, Khalid S.
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Meads, Catherine A.
United Kingdom, Uxbridge
Brunel University London
Statistics
Citations: 264
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1503/cmaj.130925
ISSN:
08203946
e-ISSN:
14882329
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Study Approach
Quantitative
Systematic review
Participants Gender
Female