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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Reduced gluteal expression of adipogenic and lipogenic genes in black South African women is associated with obesity-related insulin resistance
Journal of Clinical Endocrinology and Metabolism, Volume 96, No. 12, Year 2011
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Description
Context: Black South African women are less insulin sensitive than their White counterparts, despite less central and greater peripheral fat deposition. We hypothesized that this paradox may be explained, in part, by differences in the adipogenic capacity of sc adipose tissue (SAT). Objective: Our objective was to measure adipogenic and lipogenic gene expression in abdominal and gluteal SAT depots and determine their relationships with insulin sensitivity (SI) in South African women. Participants and Design: Fourteen normal-weight [body mass index (BMI) <25 kg/m 2] Black, 13 normal-weight White, 14 obese (BMI > 30 kg/m 2) Black, and 13 obese White premenopausal South African women participated in this cross-sectional study. Main outcomes: S I (frequently sampled iv glucose tolerance test) in relation to expression of adipogenic and lipogenic genes in abdominal and gluteal SAT depots. Results: With increasing BMI, Black women had less visceral fat (P = 0.03) and more abdominal (P = 0.017) and gynoid (P = 0.041) SAT but had lower SI (P < 0.01) than White women. The expression of adipogenic and lipogenic genes was proportionately lower with obesity in Black but not White women in the gluteal and deep SAT depots (P < 0.05 for ethnicity x BMI effect). In Black women only, the expression of these genes correlated positively with S I (all P < 0.05), independently of age and fat mass. Conclusions: Obese Black women have reduced SAT expression of adipogenic and lipogenic genes compared with White women, which associates with reduced S I. These findings suggest that obesity in Black women impairs SAT adipogenesis and storage, potentially leading to insulin resistance and increased risk of type 2 diabetes. Copyright © 2011 by The Endocrine Society.
Authors & Co-Authors
Goedecke, Julia H.
South Africa, Cape Town
University of Cape Town
South Africa, Tygerberg
South African Medical Research Council
Evans, Juliet
South Africa, Cape Town
University of Cape Town
Keswell, Dheshnie
South Africa, Cape Town
University of Cape Town
Stimson, Roland H.
United Kingdom, Edinburgh
Edinburgh Medical School
Livingstone, Dawn E.W.
United Kingdom, Edinburgh
Edinburgh Medical School
Hayes, Philip
South Africa, Cape Town
University of Cape Town
Adams, Kevin
South Africa, Cape Town
University of Cape Town
Dave, Joel A.
South Africa, Cape Town
University of Cape Town
Victor, Hendriena
South Africa, Cape Town
University of Cape Town
Levitt, Naomi S.
South Africa, Cape Town
University of Cape Town
Lambert, E. Victoria
South Africa, Cape Town
University of Cape Town
Walker, Brian Robert
United Kingdom, Edinburgh
Edinburgh Medical School
Seckl, Jonathan R.
United Kingdom, Edinburgh
Edinburgh Medical School
Olsson, Tommy
Sweden, Umea
Umeå Universitet
Kahn, Steven E.
United States, Seattle
University of Washington
Statistics
Citations: 33
Authors: 15
Affiliations: 5
Identifiers
Doi:
10.1210/jc.2011-1576
ISSN:
0021972X
e-ISSN:
19457197
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Female